The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population

Yermolenko, Svitlana; Chumachenko, Yaroslav; Orlovskyi, Viktor Feliksovych; Moiseyenko, Irina O; Orlovskyi, Oleksandr Viktorovych

doi:10.1155/2021/5596974

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Apo lipoprotein E (APOE) ( Rao et al, 2022 ), Angiotensinogen II Type 1 Receptor (AGTR1) ( Wulandari et al, 2018 ), Angiotensin-converting enzyme (ACE) ( Ya et al, 2019 ), methylenetetrahydrofolate reductase (MTHFR) ( Garakanidze et al, 2018 ), endothelin1 (EDN1) ( Yang et al, 2021 ), ring finger protein 213 (RNF213) ( Suzuki et al, 2018 ), Alpha-Adducin 1 (ADD1) ( Yermolenko et al, 2021 ), tumor necrosis factor (TNF) ( Khlynova et al, 2020 ) and T-box transcription factor 2 (TBX2) ( Abramova et al, 2020 ) involve in the AH process and the overexpression of them can cause amplification in AH.…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Karabaeva,

Vochshenkova,

Zare

et al. 2023

Front. Mol. Biosci.

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Introduction: Arterial hypertension (AH) is a pervasive global health concern with multifaceted origins encompassing both genetic and environmental components. Previous research has firmly established the association between AH and diverse genetic factors. Consequently, scientists have conducted extensive genetic investigations in recent years to unravel the intricate pathophysiology of AH.Methods: In this study, we conducted a comprehensive bibliometric analysis employing VOSviewer software to identify the most noteworthy genetic factors that have been the focal point of numerous investigations within the AH field in recent years. Our analysis revealed genes and microRNAs intricately linked to AH, underscoring their pivotal roles in this condition. Additionally, we performed molecular docking analyses to ascertain microRNAs with the highest binding affinity to these identified genes. Furthermore, we constructed a network to elucidate the in-silico-based functional interactions between the identified microRNAs and genes, shedding light on their potential roles in AH pathogenesis.Results: Notably, this pioneering in silico examination of genetic factors associated with AH promises novel insights into our understanding of this complex condition. Our findings prominently highlight miR-7110-5p, miR-7110-3p, miR-663, miR-328-3p, and miR-140-5p as microRNAs exhibiting a remarkable affinity for target genes. These microRNAs hold promise as valuable diagnostic and therapeutic factors, offering new avenues for the diagnosis and treatment of AH in the foreseeable future.Conclusion: In summary, this research underscores the critical importance of genetic factors in AH and, through in silico analyses, identifies specific microRNAs with significant potential for further investigation and clinical applications in AH management.

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Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Karabaeva,

Vochshenkova,

Zare

et al. 2023

Front. Mol. Biosci.

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“…[45] ADD1 gene, which produces alpha-adducin protein is pivotal for regulating sodium transport in kidney. [46] Increased sodium retention elevates blood volume, subsequently raising blood pressure, making sodium reabsorption a critical determinant of blood pressure. [47] Genetic changes in the ADD1 gene can disrupt alpha-adducin's sodium regulation, leading to elevated blood pressure.…”

Section: Alpha-adducin (Add1) Genementioning

confidence: 99%

Genetic Factors Associated with Hypertension: A Comprehensive Review

Shabaraya A,

D Shetty

2023

Int J Res Rev

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Recent scientific findings indicate that hypertension is a largely genetically driven condition; one of today’s leading global health issues. There are many identified gene mutations associated with different aspects involving blood pressure control that lead to hypertension. More recently, certain specific genetic variants related to blood pressure control have been found using the modern techniques of genetic analysis that may assist in developing custom strategies to prevent and treat hypertension. The aim of this article is to highlight genetic aspects of hypertension and use them to establish individual therapy. It looks at the influence of genetic diversity on sodium resorption, skeletal muscle contraction, and drug pharmacokinetics. These studies indicate that GWAS has identified some genetic variants for hypertension and developed some genetic risk score (GRS) which can be used for prediction purpose. Therefore, genetic contribution is significant in establishing as well as sustaining high blood pressure. Knowledge about genetics regarding hypertension may change the way it is addressed on a person-by-person basis. Nevertheless, research needs to tackle the challenge of validating associations among diverse populations while developing a mechanism for translating genetic findings into clinical practice. Thus, we would enhance preventive, diagnostic and therapeutic measures for many people globally. Keywords: Hypertension; Genetic factors; Blood pressure regulation; Genome-wide association studies (GWAS); Personalized medicine approaches.

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Ions and Fluid Dynamics in Hypertension

Traum

2023

Pediatric Hypertension

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The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population

Cited by 6 publications

References 38 publications

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Genetic Factors Associated with Hypertension: A Comprehensive Review

Ions and Fluid Dynamics in Hypertension

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