The association between endometriosis and ovarian cancer: A review of histological, genetic and molecular alterations

Munksgaard, Peter Svenssen; Blaakær, Jan

doi:10.1016/j.ygyno.2011.10.001

Cited by 204 publications

(160 citation statements)

References 83 publications

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“…Even though endometriosis is considered to be a benign condition, it does share common characteristics with malignant cells. 4 Few similar studies also substantiate this and our study also finds similar results.…”

Section: Discussionsupporting

confidence: 89%

Association of Ovarian Cancer Risk with Other Gynaecological Diseases in Women- An Observational Study

Sam¹

2018

jmscr

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Section: Discussionsupporting

confidence: 89%

Association of Ovarian Cancer Risk with Other Gynaecological Diseases in Women- An Observational Study

Sam¹

2018

jmscr

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“…Resiko keganasan epitel ovarium meningkat sebanyak 3 kali lipat (resiko relatif 1.9 sampai 4.2) (Keita et al, 2010;Munksgaard & Blaakaer 2011;Furuya, 2012;Robboy et al, 2009).Karsinoma endometrioid, karsinoma sel jernih, karsinoma serosum, dan karsinoma musinosum, termasuk di dalamnya (Furuya, 2012;Robboy et al, 2009;Terada T, 2012;Worley et al, 2013;Macciò, and Madeddu, C 2012;Koshiyama et al, 2014;Gerard et al, 2004).Bukan hal mudah menegakkan diagnosis EAOC.Sel-sel ganas mampu merusak dan merubah stroma sekitarnya, termasuk jaringan endometriosis di mana dia berasal (Furuya, 2012). Penelitian di Jepang tahun 2012, selama 15 tahun, hanya ditemukan 15 kasus karsinoma endometrioid ovarium dan hanya 40% di antaranya yang disertai lesi endometriosis (Terada, 2012).Pada penelitian ini, selama periode 2012 -2014 ditemukan 11 sampel karsinoma endometrioid ovarium, tanpa disertai lesi endometriosis, begitu pula pada 11 sampel karsinoma serosum ovarium.…”

Section: Hasil Dan Pembahasanunclassified

“…Hormon ini akan memicu COX-2, yang menyebabkan peningkatan sintesa PGE2. Kadar PGE2 yang tinggi akan merangsang aktivitas aromatase sehingga terjadi positive feedback loop pembentukan estradiol (Munksgaard & Blaakaer 2011;Sourial et al, 2014).…”

Section: Hasil Dan Pembahasanunclassified

Ekspresi Interleukin-1 (Il-1) Β Pada Endometriosis, Karsinoma Endometrioid Dan Karsinoma Serosum Ovarium

Lestari¹,

Amarwati²,

Sadhana³

et al. 2017

Biomedika

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ABSTRAK Kata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum ABSTRACT Ovarian endometriosis is associated with an increased risk of ovarian epithelial carcinoma (RR 1.9-4.2). Endometrioid carcinoma is one of the most common type of malignancy associated with endometriosis, while serous carcinoma is the most common ovarian cancer type. It has been reported that sera pro-inflammatory interleukin-1 (IL-1) β evidently be involved in both endometriosis (p = 0,034 and p=0,020), while group B vs group C was not significant (p = 0,805). There are some differences in IL-1β expression among ovarian endometriosis, endometrioid carcinoma, and serosum carcinoma, but there are no significantly difference between ovarian endometrioid carcinoma and serosum carcinoma.

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“…In china, the burden of ovary cancer will continue to be relative stable due to the aging population (Wang, 2014). Although the molecular etiology about OC was continuously investigated (Samuels et al, 2011;Munksgaard et al, 2012), the overall survival rate of OC was still not improved in the last 20 to 30 years (Vaughan et al, 2011). In Robert's study, the poor prognosis of OC was usually attributed to advanced stage at diagnosis and inadequate chemotherapy (Burger et al, 2011), but it was difficult to solve these technical problems.…”

Section: Introductionmentioning

confidence: 99%

Recreational Physical Activity and Risk of Ovarian Cancer: a Meta-analysis

Zhou¹

2014

Asian Pacific Journal of Cancer Prevention

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Our aim was to access the association between recreational physical activity (RPA) and risk of ovarian cancer (OC). The studies were retrieved from the PubMed and Embase databases up to February 20th, 2014. Risk ratios (OR) and 95% confidence intervals (CI) were used to estimate effect sizes. Random-effects or fixed-effects models were used to pool the data. The trim and fill method was applied for sensitivity analysis. Begg's rank correlation test and Egger's regression asymmetry test were employed to assess the publication bias. A total of 6 studies (435398 participants including 2983 OC patients) were included in this meta-analysis. The overall estimate indicated that there was weakly inverse association between RPA and OC risk (RR=0.90, 95%CI: 0.72-1.12, p=0.335). Meanwhile, for prospective cohort studies, a result consistent with the overall estimate was obtained (RR=1.12, 95% CI: 0.88-1.42, p=0.356). However, for case control studies, the pooled estimate of RR was 0.76 (95%CI: 0.64-0.90, p=0.002), indicating a clear significant association between RPA and OC risk. In addition, the sensitivity analysis indicated a significant link between RPA and risk of OC after removing Lahmann's study (RR=0.80, 95% CI: 0.68-0.93, p=0.004). No significant publication bias was found (Begg's test: p=1.00; Egger's test: p=0.817). In conclusion, our meta-analysis indicated a weakly inverse relationship between RPA and the occurrence of OC.

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The association between endometriosis and ovarian cancer: A review of histological, genetic and molecular alterations

Cited by 204 publications

References 83 publications

Association of Ovarian Cancer Risk with Other Gynaecological Diseases in Women- An Observational Study

Association of Ovarian Cancer Risk with Other Gynaecological Diseases in Women- An Observational Study

Ekspresi Interleukin-1 (Il-1) Β Pada Endometriosis, Karsinoma Endometrioid Dan Karsinoma Serosum Ovarium

Recreational Physical Activity and Risk of Ovarian Cancer: a Meta-analysis

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