The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: Involvement of GABAA receptor

Carro‐Juárez, Miguel; Rodríguez‐Landa, Juan Francisco; Rodríguez-Peña, María de Lourdes; Rovirosa-Hernández, María de Jesús; García-Orduña, Francisco

doi:10.1016/j.jep.2012.07.022

Cited by 31 publications

(22 citation statements)

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“…In the present study, as the stress hormone corticosterone was measured as the rats were subjected to both EPM and OF tests. These two tests were performed in two adjacent rooms, the delay time was less than one minute, and we thought that these procedures might not influence the effectiveness of the drug or plasma corticosterone concentrations, which were also used by other researchers [34, 35]. Our data showed that valtrate (10 mg/kg), a dose which produced anxiolytic activity in the behavioural experiments, attenuated the activity of HPA axis by reducing the corticosterone response to the stress of exposure to the elevated plus maze.…”

Section: Discussionmentioning

confidence: 99%

The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

Shi

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Valtrate is a principle compound isolated from Valeriana jatamansi Jones, which is a Traditional Chinese Medicine used to treat various mood disorders. The aim of the present study was to investigate the anxiolytic effects of valtrate in rats. The animals were orally administered valtrate (5, 10, and 20 g/kg daily) for 10 days and exposed to open field test (OFT) and elevated plus-maze (EPM). Then the corticosterone levels in the rat serum were measured by enzyme-linked immunosorbent assay (ELISA). The valtrate (10 mg/kg, p.o.) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the EPM and the number of central entries in the OFT. Valtrate (10 mg/kg, p.o.) significantly reduced the corticosterone level in the rat serum. Taken together, these results suggest that the valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis.

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Section: Discussionmentioning

confidence: 99%

The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

Shi

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…The aqueous crude extract from these plants has been used for centuries in traditional Mexican medicine as a remedy for reproductive impairments, anxiety, and mood disorders [16–19]. Recently, the aqueous extracts of M. tomentosa [20] and M. frutescens [21] were reported to produce anxiolytic-like effects that are similar to diazepam in Wistar rats, and the participation of γ -aminobutyric acid-A (GABA A ) receptors in their anxiolytic-like effect was identified. Nonetheless, although some anxiolytic-like effects of M. frutescens extract have been corroborated in male rats, the anxiolytic-like effects of M. frutescens and M. grandiflora in the female genus remain unexplored.…”

Section: Introductionmentioning

confidence: 99%

Montanoa frutescensandMontanoa grandifloraExtracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

Rodríguez‐Landa

Vicente-Serna

Rodríguez-Blanco

et al. 2014

BioMed Research International

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In previous studies, the anxiolytic-like effects of Montanoa tomentosa and Montanoa frutescens were reported in male rats, but the potential anxiolytic-like effects of Montanoa plants during the different phases of the ovarian cycle in rats remain to be explored. The anxiolytic-like effects of the aqueous crude extracts of M. frutescens (25 and 50 mg/kg) and M. grandiflora (25 and 50 mg/kg) in the elevated plus maze were investigated in Wistar rats during the estrous cycle and compared with 2 mg/kg diazepam as a reference anxiolytic drug. To investigate any motor effect (i.e., hyperactivity, no changes, or hypoactivity) associated with the treatments, the rats were evaluated in the open field test. The M. frutescens (25 and 50 mg/kg) and M. grandiflora (50 mg/kg) extracts exerted anxiolytic-like effects during the metestrus-diestrus phase, similar to diazepam, without disrupting spontaneous motor activity. No significant effects of the extracts were detected in either behavioral test during the proestrus-estrus phase, whereas diazepam produced motor hypoactivity in the open field test. These results indicate that the M. frutescens and M. grandiflora extracts possess anxiolytic-like effects that depend on the ovarian cycle phase, supporting the Mexican ancient medicinal use of these plants to ameliorate anxiety disorders.

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“…In this respect, several plants are traditionally and clinically used for the management of neurological disorders. From our previous research and others, several plants and herb preparations were demonstrated to protect against neuronal damage [7], Parkinson and Alzheimer' disease [8, 9], to improve neuronal differentiation [10], and to act against depression [11, 12], epilepsy [13], and anxiety [14]. …”

Section: Introductionmentioning

confidence: 99%

Antistress Effects of the Ethanolic Extract fromCymbopogon schoenanthusGrowing Wild in Tunisia

Othman

Han

Omri

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This study aimed to investigate the antistress properties of the ethanol extract of Cymbopogon schoenanthus (CSEE), growing wild in the southern part of Tunisia. The effect of extracts on H2O2-induced cytotoxicity and stress in human neuroblastoma SH-SY5Y cells. Its effect on stress-induced in ICR mice was exposed to force swim and tail suspension, in concordance with heat shock protein expression (HSP27 and HSP90), corticosterone, and catecholamine neurotransmitters level. Our results demonstrated that pretreatment of SH-SY5Y cells with CSEE at 1/2000, 1/1000, and 1/500 v/v dilutions significantly inversed H2O2-induced neurotoxicity. Moreover, CSEE treatments significantly reversed heat shock protein expression in heat-stressed HSP47-transformed cells (42°C, for 90 min) and mRNA expression of HSP27 and HSP90 in H2O2-treated SH-SY5Y. Daily oral administration of 100 mg/kg and 200 mg/kg CSEE was conducted to ICR mice for 2 weeks. It was resulted in a significant decrease of immobility time in forced swimming and tail suspension tests. The effect of CSEE on animal behavior was concordant with a significant regulation of blood serum corticosterone and cerebral cortex levels of catecholamine (dopamine, adrenaline, and noradrenaline). Therefore, this study was attempted to demonstrate the preventive potential of CSEE against stress disorders at in vitro and in vivo levels.

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The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: Involvement of GABAA receptor

Cited by 31 publications

References 50 publications

The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

Montanoa frutescensandMontanoa grandifloraExtracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

Antistress Effects of the Ethanolic Extract fromCymbopogon schoenanthusGrowing Wild in Tunisia

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