<i>Montanoa frutescens</i>and<i>Montanoa grandiflora</i>Extracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

Rodríguez‐Landa, Juan Francisco; Vicente-Serna, Julio; Rodríguez-Blanco, Luis Alfredo; Rovirosa-Hernández, María de Jesús; García-Orduña, Francisco; Carro‐Juárez, Miguel

doi:10.1155/2014/938060

Cited by 26 publications

(14 citation statements)

References 51 publications

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“…These findings are interesting because the traditional use of this plant extract had been recommended in the ancient traditional medicine from México, as it was described in the Badianus Codex or Libellus de Medicinalibus Indorum Herbis (1552). It supports the potential use of this extract in the future as a natural alternative to ameliorate anxiety symptoms related with changes in ovarian hormones [84,85].…”

Section: Ovariectomized Rats As An Animal Model For Surgical Menopausesupporting

confidence: 52%

“…In an early study, the effect of an aqueous extract of Montanoa tomentosa in rats with a longterm absence of ovarian hormones was evaluated [84]. In this study, the acute administration of the extract produced a significant reduction of anxiety-like behaviour when rats were evaluated in the elevated plus maze.…”

Section: Ovariectomized Rats As An Animal Model For Surgical Menopausementioning

confidence: 97%

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Anxiety in Natural and Surgical Menopause — Physiologic and Therapeutic Bases

Rodríguez‐Landa¹,

Puga-Olguín²,

JesúsGermán-Ponciano³

et al. 2015

A Fresh Look at Anxiety Disorders

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Generalized anxiety disorder is one of the most common psychiatric disorders, affecting a high percentage of human beings around the world. This emotional disorder possesses marked gender differences and occurs more often in women than in men, in a proportion of . Accompanying the reproductive cycle of women are significant fluctuations in plasma and brain steroid hormone concentrations, including oestradiol, progesterone, and allopregnanolone, among others. These hormonal changes are related to some illnesses and with the development of anxiety and mood swings occurring in the premenstrual and postpartum period, and particularly during the menopause. Menopause is a clinical term used to indicate the cessation of the woman's reproductive ability that occurs naturally, but also may be surgically induced by bilateral oophorectomy, with or without the removal of the Fallopian tubes and uterus. Natural menopause includes specific periods related to the physiological and hormonal changes produced by ovarian failure, it is usually a natural stage that occurs to women in midlife, during their late s or early s, indicating the end of the reproductive period in the woman. During the menopause transition years, women experience changes in the production of ovarian hormones, which are associated with significant changes in the physiological, emotional, and affective processes. Unfortunately, surgical menopause occurs at an early age, and produces similar physiological and psychiatric disorders, but they are more severe in this instance. In both cases, typical symptoms associated with menopause critically deteriorate the mental health of the women. In this way, the therapeutic management of clinical symptoms of menopause include replacement hormone therapy, the use of anxiolytic and antidepressant drugs, and other natural alternatives based on the use of chemical compounds obtained from plants such as soya. However, a general effective treatment for menopause symptoms does not yet exist. For this reason, experimental studies have proposed ovariectomy in rats as a potential tool to study the effects of a long-term absence of ovarian hormones associated with surgical menopause, which also allowed the study of substances with potential therapeutic application to ameliorate typical symptoms associated with surgical menopause. The aim of this chapter is to review the participation of ovarian hormones in the regulation of emotional and affective disorders in women with natural or surgical menopause particularly their anatomical pathways, neurotransmission systems, and the resulting behavioural patterns. Finally, preclinical and clinical research suggested that longterm absence of ovarian hormones associated with natural or surgical menopause is the principal cause of physiological and psychiatric disorder in the women therefore, oestrogenic compounds seem to play an important role in the maintenance of the brain structures that regulate anxiety, mood, memory, and cognitive functions in menopausal women.

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Section: Ovariectomized Rats As An Animal Model For Surgical Menopausesupporting

confidence: 52%

Section: Ovariectomized Rats As An Animal Model For Surgical Menopausementioning

confidence: 97%

Anxiety in Natural and Surgical Menopause — Physiologic and Therapeutic Bases

Rodríguez‐Landa¹,

Puga-Olguín²,

JesúsGermán-Ponciano³

et al. 2015

A Fresh Look at Anxiety Disorders

Self Cite

View full text Add to dashboard Cite

show abstract

“…The following variables were evaluated: (i) time spent on the open arms, (ii) number of entries into the open arms, (iii) total number of arm entries (open arms + closed arms), and (iv) percentage of open arm entries ([open arm entries]/[total arm entries] × 100). These variables were selected based on previous studies, providing a reliable measure of experimental anxiety [ 35 – 37 ]. After the elevated plus maze test, the rats were evaluated in the locomotor activity test.…”

Section: Methodsmentioning

confidence: 99%

The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

Rodríguez‐Landa

Cueto‐Escobedo

Puga-Olguín

et al. 2017

BioMed Research International

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The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. However, no studies have directly compared the effects of identical doses of genistein and 17β-estradiol, the main estrogen used in hormone replacement therapy in menopausal women. The present study evaluated the anxiolytic-like effects of identical doses of genistein and 17β-estradiol (0.045, 0.09, and 0.18 mg/kg/7 days, s.c.) in a surgical menopause model in rats in the elevated plus maze and locomotor activity tests at 12 weeks after ovariectomy. Additionally, the participation of estrogen receptor-β in the anxiolytic-like effect of genistein and 17β-estradiol was explored by previous administration of the 5 mg/kg tamoxifen antagonist. Genistein and 17β-estradiol (0.09 and 0.18 mg/kg) similarly reduced anxiety-like behavior in the elevated plus maze and also increased the time spent grooming and rearing, without affecting crossing in locomotor activity test. These effects were blocked by tamoxifen. Present results indicate that the phytoestrogen genistein has a similar behavioral profile as 17β-estradiol in rats at 12 weeks after ovariectomy through action at the estrogen receptor-β. Thus genistein has potential for reducing anxiety-like behavior associated with low concentrations of ovarian hormones, which normally occurs during natural and surgical menopause.

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“…Cihuapatli is the common name assigned to some plants of the genus Montanoa (family: Asteraceae; tribe: Heliantheae), in which M. frutescens and M. grandiflora are included (Rodríguez‐Landa et al., ). Carro‐Juárez, Franco, and Rodríguez‐Peña Mde () investigated comparative aphrodisiac activity of M. grandiflora and M. frutescens using the fictive ejaculation model in spinal male rats.…”

Section: Medicinal Plants Andplant‐derived Products Used As Aphrodisimentioning

confidence: 99%

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

Malviya¹,

Malviya²,

Jain³

et al. 2016

Andrologia

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Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human being's life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction.

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Montanoa frutescensandMontanoa grandifloraExtracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

Cited by 26 publications

References 51 publications

Anxiety in Natural and Surgical Menopause — Physiologic and Therapeutic Bases

Anxiety in Natural and Surgical Menopause — Physiologic and Therapeutic Bases

The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction

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