The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels

Shi, Shu-Ning; Shi, Jingping; Liu, Yong; Wang, Yanli; Wang, Chun-Guo; Hou, Wenhui; Guo, Jian-You

doi:10.1155/2014/325948

Cited by 27 publications

(26 citation statements)

References 31 publications

(28 reference statements)

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“…Valtrate ( 1 ) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the elevated plus maze and the number of central entries in the open field test. Furthermore, it significantly reduces the corticosterone level in the rat serum, which clearly suggests the anxiolytic activity of valtrate ( 1 ) in behavioral models possibly mediated via the function of hypothalamus–pituitary–adrenal axis (Shi et al, ). Gene chip technology was used to investigate the gene expression difference among apoptosis‐related genes in normal rats, anxiety model rats, and rats administred with V. jatamansi extract.…”

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 98%

“…6‐Methylapigenin ( 149 ) functioned as a competitive ligand for the brain GABA A receptors (Wasowski, Marder, Viola, Medina, & Paladini, ). Shi et al () investigated the anxiolytic effects of valtrate ( 1 ) in rats by oral administration with different doses followed by subsequent exposure to open field test and elevated plus maze. Valtrate ( 1 ) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the elevated plus maze and the number of central entries in the open field test.…”

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 99%

“…The extract of the species was used for lowering blood pressure and strengthening and palpitations of the heart (Morazzoni & Bombardelli, 1995). Gilani, Khan, Jabeena, Subhan, and Ghafar (2005) which clearly suggests the anxiolytic activity of valtrate (1) in behavioral models possibly mediated via the function of hypothalamus-pituitary-adrenal axis (Shi et al, 2014). Gene chip technology was used to investigate the gene expression difference among apoptosis-related genes in normal rats, anxiety model rats, and rats administred with V. jatamansi extract.…”

Section: Cytotoxic Effectsmentioning

confidence: 99%

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Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known. For instance, V. jatamansi is very important for its insect repelling and antihelmethic properties. Similarly, sedative, neurotoxic, cytotoxic, antidepressant, antioxidant, and antimicrobial activities of the species in various ailments in the indigenous system of medicine, particularly in Asia, are reported. This review focuses on the detailed phytochemical composition, medicinal uses, and pharmacological properties of V. jatamansi along with analysis of botanical errors in published literature and reproducibility of the biomedical researches on this multipurpose herbaceous species.

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Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 98%

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 99%

Section: Cytotoxic Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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“…The presence of valtrate was confirmed in the TL chromatogram of the extract. Thus, the antianxiety and antidepressant activity of V. pyrolaefolia is attributable to the presence of valtrate as it is reported to be the anxiolytic principle of other species of valerian [14][15][16][17] .…”

Section: Antidepressant Activitymentioning

confidence: 96%

“…EPM is a well-established and most widely used animal model in contemporary preclinical research on anxiety. Fear due to height induces anxiety in the animals when placed on the EPM 12,14 . Antianxiety effect of the extract was compared with the standard antianxiety drug diazepam.…”

Section: Antidepressant Activitymentioning

confidence: 99%

Untitled

2019

IJPSR

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Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt's despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral route. The dichloromethane extract of V. pyrolaefolia roots exhibited significant dose-dependent antianxiety activity at 400 mg/kg. The results were comparable to the standard diazepam (2 mg/kg). The extract also exhibited significant antidepressant activity at 400 mg/kg dose. The results were comparable to the standard imipramine (10 mg/kg). The TLC fingerprint profile of the bioactive extract was developed using precoated TLC plates of 0.2 mm thickness. Valtrate was used as a bioactive marker for developing TLC fingerprint profile. The solvent system comprising dichloromethane: ethyl methyl ketone (8: 2) was used for developing the TLC profile. The TL chromatogram showed valtrate as a major component of the extract.

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