Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody

Howe, W E; Venables, K M; Topping, M. D.; Dally, M B; Hawkins, R; Law, Jade; Taylor, A J Newman

doi:10.1016/0091-6749(83)90539-0

Cited by 110 publications

(33 citation statements)

References 8 publications

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“…There was a relationship between the degree of exposure and the prevalence of work-related symptoms. A follow-up study of 39 workers with asthma due to colophony exposure showed that symptoms persisted in half of them up to 4 yrs after exposure ceased [119].…”

Section: Colophony and Fluxesmentioning

confidence: 99%

Aetiological agents in occupational asthma

Chan‐Yeung¹,

Malo²

1994

Eur Respir J

210

111

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A Ae et ti io ol lo og gi ic ca al l a ag ge en nt ts s i in n o oc cc cu up pa at ti io on na al l a as st th hm ma a M. Chan-Yeung*, J-L. Malo** Aetiological agents in occupational asthma. M. Chan-Yeung, J-L. Malo. ERS Journals Ltd 1994. ABSTRACT: Occupational asthma has become the most prevalent occupational lung disease in developed countries. At present, about 200 agents have been implicated in causing occupational asthma in the workplace. These agents can be divided into two categories by their mechanism of action: immunological and nonimmunological.Immunological causes can be further divided into those that induce asthma through an immunoglobulin E (IgE)-dependent mechanism, and those that induce asthma through a non-IgE-dependent mechanism. In the latter category, specific IgE antibodies are found only in a small percentage of the patients with proven disease, even though the clinical picture is compatible with an allergic reaction. The immunological mechanism(s) responsible for these agents has yet to be identified.The best known example of nonimmunological asthma is Reactive Airways Dysfunction Syndrome (RADS) or irritant-induced asthma.In this review, examples of types of agents causing occupational asthma are discussed and a compendium table of aetiological agents is given. Eur Respir J., 1994, 7, 346-371.

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Section: Colophony and Fluxesmentioning

confidence: 99%

Aetiological agents in occupational asthma

Chan‐Yeung¹,

Malo²

1994

Eur Respir J

210

111

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“…Among the organic acid anhydrides, phthalic anhydride (PA), tetrahydrophthalic anhydride, tetrachlorophthalic anhydride, hexahydrophthalic anhydride, trimellitic anhydride, himic anhydride, and maleic anhydride are all known sensitizing agents, causing symptoms of the eyes and airways (1)(2)(3)(4)(5)(6)(7)(8). As these agents have, in addition, strong irritating properties, high frequencies of complaints have been reported in exposed worker populations (5,9,10).…”

mentioning

confidence: 99%

Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin.

Nielsen¹,

Welinder²,

Skerfving³

1989

Scand J Work Environ Health

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“…There are a few exceptions in which the presence of specific serum IgE and/or a positive SPT are considered a sensitive diagnostic aid, e.g. to complex (unconjugate) platinum salts, trimellitic and acid anhydrides [18,19]. In the case of LMW compounds, particularly some of the most common causes of OA, like isocyanates, the sensitivity and specificity of tests assessing the IgE response is variable, being good for some [20] and less satisfactory for others [21,22].…”

Section: Immunological Assessmentmentioning

confidence: 99%

Diagnosing occupational asthma: how, how much, how far?: Table 1

Moscato

Jl²,

Bernstein³

2003

Eur Respir J

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Diagnosing occupational asthma is still a challenge because it is based on a stepwise approach in which the depth of investigative means may vary depending on resources. The authors herewith review the existing investigative means from the approach of outlining controversies and queries.There is no validated clinical questionnaire for diagnosing occupational asthma. Immunological investigation is limited by the lack of standardised extracts for skinprick testing and specific immunoglobulin E assessments. Criteria for interpretation of changes in peak expiratory flow rates and bronchial responsiveness to pharmacological agents are still open to discussion.It is worth improving the methodology of specific inhalation challenges, either in the laboratory or in the workplace, to facilitate more extensive use of these tests. Validation of new means that assess airway inflammation, such as exhaled nitric oxide and induced sputum, needs to be performed. There is a need to increase the use of these diagnostic tests because the diagnosis is still too often based on "clinical impression". Eur Respir J 2003; 21: 879-885.

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Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody

Cited by 110 publications

References 8 publications

Aetiological agents in occupational asthma

Aetiological agents in occupational asthma

Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin.

Diagnosing occupational asthma: how, how much, how far?: Table 1

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