No abstract

No abstract

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.

Background:The prevalence of asthma has increased in developed countries in the past 2 decades. The effectiveness of intervention measures on the primary prevention of asthma has not been well studied.

Although residential greenness appears to be associated with childhood allergic rhinitis and aeroallergen sensitization, the effect direction varies by location.

No abstract

A Ae et ti io ol lo og gi ic ca al l a ag ge en nt ts s i in n o oc cc cu up pa at ti io on na al l a as st th hm ma a M. Chan-Yeung*, J-L. Malo** Aetiological agents in occupational asthma. M. Chan-Yeung, J-L. Malo. ERS Journals Ltd 1994. ABSTRACT: Occupational asthma has become the most prevalent occupational lung disease in developed countries. At present, about 200 agents have been implicated in causing occupational asthma in the workplace. These agents can be divided into two categories by their mechanism of action: immunological and nonimmunological.Immunological causes can be further divided into those that induce asthma through an immunoglobulin E (IgE)-dependent mechanism, and those that induce asthma through a non-IgE-dependent mechanism. In the latter category, specific IgE antibodies are found only in a small percentage of the patients with proven disease, even though the clinical picture is compatible with an allergic reaction. The immunological mechanism(s) responsible for these agents has yet to be identified.The best known example of nonimmunological asthma is Reactive Airways Dysfunction Syndrome (RADS) or irritant-induced asthma.In this review, examples of types of agents causing occupational asthma are discussed and a compendium table of aetiological agents is given. Eur Respir J., 1994, 7, 346-371.

No abstract