A Randomized Controlled Study on the Effectiveness of a Multifaceted Intervention Program in the Primary Prevention of Asthma in High-Risk Infants

Abstract

Background:The prevalence of asthma has increased in developed countries in the past 2 decades. The effectiveness of intervention measures on the primary prevention of asthma has not been well studied.

Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature

“…Specifically, in the Cochrane review, a 16% decreased risk of eczema among infants receiving PHF-W compared with infants receiving intact protein cow's milk formula was observed, but this result did not reach statistical significance and was based on data from only six studies. 21,24,28,30,34,40 These results are generally consistent with the conclusions reached in our assessment, although the present review includes 11 publications, 22,23,26,29,[31][32][33][35][36][37][38] representing seven independent infant populations not included in the Cochrane review. In addition, we included two updated studies 16,25 of an earlier publication.…”

Adherence to allergy prevention recommendations in children with a family history of asthma

“…Adherence regarding the use of mattress covers was relatively high (>80% from 6 to 12 months), which is consistent with the finding of Halmerbauer et al. that the average time of mattress cover use was >85% of the children’s sleeping time (18), and that of Chan‐Yeung et al., where >90% of the subjects complied with bedding covers and acaricide application over 12 months (14). At 4 yr of age in the prevention and incidence of asthma and mite allergy (PIAMA) study, there was still 87% adherence with mattress cover use (23).…”

Effect of Allergen Concentrations on Symptoms of Asthma at 18 Months

“…In practice, for public health interventions, it is important to ascertain the effects of reducing allergen exposure in situations where other confounders cannot be controlled. It is difficult to reconcile our results with the results of the three primary prevention studies that have been reported [7][8][9] and that have all shown effectiveness of allergen avoidance in reducing symptoms from an early age. However, the differences in methods between these studies and our own are quite marked.…”

“…It is difficult to reconcile our results with the results of the three primary prevention studies that have been reported [7][8][9] and that have all shown effectiveness of allergen avoidance in reducing symptoms from an early age. However, the differences in methods between these studies and our own are quite marked.…”