Terminalia chebula extracts ameliorate methamphetamine-induced memory deficits via activating the ERK and Nrf2 pathway

Zeng, Qing; Xiong, Qi; Lin, Kuan; Zheng, Lirong; Xiang, Tian; Xu, Congyue; Ru, Qin

doi:10.1016/j.brainresbull.2022.04.002

Cited by 6 publications

(3 citation statements)

References 62 publications

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“…Bands were visualized with the GENE GNOME SYNGENE BIO IMAGING system (version Gene Sys, Gene company, Hong Kong, China). Prefrontal cortical neurons were isolated, as reported previously, with some modifications [97,98]. Newborn SD mice (day 0) were rapidly sacrificed by decapitation.…”

Section: Western Blot Analysismentioning

confidence: 99%

Alcohol Exposure Induces Depressive and Anxiety-like Behaviors via Activating Ferroptosis in Mice

Xiong

Xiang

et al. 2022

IJMS

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Alcohol use disorder (AUD) is a global public health problem and is frequently comorbid with mental disorders, including anxiety and depression. Ferroptosis is an iron-dependent cell death, which is involved in the pathological process of various diseases such as neurodegenerative diseases, but the role of ferroptosis in the mediation of AUD and its induced mental disorders is unclear. In this study, we aimed to investigate whether ferroptosis was involved in alcohol-induced depressive and anxiety-like behaviors in mice. Following an 8-week period of intermittent alcohol exposure, the alcohol group showed noticeable depressive and anxiety-like behaviors. In addition, nissl staining revealed that alcohol exposure induced neuron damage in the hippocampus (Hip) and prefrontal cortex (PFC) of mice. The levels of synapse-related proteins were significantly reduced in the alcohol group. Iron staining demonstrated that alcohol increased the number of iron-positive staining cells. The protein expression of the transferrin receptor (TFRC) was increased, and the expression of glutathione peroxidase 4 (GPX4) was decreased, respectively, in the alcohol group. Furthermore, the ferroptosis inhibitor ferrostatin-1 significantly prevented alcohol-induced neuron damage and enhanced the expression of N-methyl-d-aspartic acid (NMDA) receptor 2B (NR2B), α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor 1 (GluA1) and GPX4 in vitro. These results indicated that alcohol exposure could induce depressive and anxiety-like behaviors, and that this effect may occur via activating ferroptosis.

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Section: Western Blot Analysismentioning

confidence: 99%

Alcohol Exposure Induces Depressive and Anxiety-like Behaviors via Activating Ferroptosis in Mice

Xiong

Xiang

et al. 2022

IJMS

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“…According to Jung et al [ 26 ], chebulic acid upregulated Nrf2, glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase modifier subunit, and heme oxygenase-1 (HO-1) expression in vitro. Zeng et al [ 84 ] found that Terminalia chebula retzius extracts activated the Nrf2 pathway. Lin et al [ 85 ] also found that polyphenol extracts from Terminalia chebula Retz.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Terminalia chebula Extract on Growth Performance, Immune Function, Antioxidant Capacity, and Intestinal Health of Broilers

Cheng,

Liu,

Wang

et al. 2024

Animals

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Terminalia chebula extract (TCE) has many physiological functions and is potentially helpful in maintaining poultry health, but its specific effect on the growth of broilers is not yet known. This research investigated the effects of dietary Terminalia chebula extract (TCE) supplementation on growth performance, immune function, antioxidant capacity, and intestinal health in yellow-feathered broilers. A total of 288 one-day-old yellow-feathered broilers were divided into four treatment groups (72 broilers/group), each with six replicates of 12 broilers. The broilers were given a basal diet of corn–soybean meal supplemented with 0 (control), 200, 400, and 600 mg/kg TCE for 56 d. The results demonstrated that, compared with the basal diet, the addition of TCE significantly increased (linear and quadratic, p < 0.05) the final body weight and overall weight gain and performance and decreased (linear and quadratic, p < 0.05) the feed-to-gain ratio in the overall period. Dietary TCE increased (linear, p < 0.05) the levels of IgM, IL-4, and IL-10 and decreased (linear and quadratic, p < 0.05) the level of IL-6 in the serum. Dietary TCE increased (linear and quadratic, p < 0.05) the levels of IL-2 and IL-4, decreased (linear and quadratic, p < 0.05) the level of IL-1β, and decreased (linear, p < 0.05) the level of IL-6 in the liver. Dietary TCE increased (linear and quadratic, p < 0.05) the level of IgM and IL-10, increased (linear, p < 0.05) the level of IgG, and decreased (linear and quadratic, p < 0.05) the levels of IL-1β and IL-6 in the spleen. Supplementation with TCE linearly and quadratically increased (p < 0.05) the catalase, superoxide dismutase, glutathione peroxidase, and total antioxidant capacity activities while decreasing (p < 0.05) the malonic dialdehyde concentrations in the serum, liver, and spleen. TCE-containing diets for broilers resulted in a higher (linear and quadratic, p < 0.05) villus height, a higher (linear and quadratic, p < 0.05) ratio of villus height to crypt depth, and a lower (linear and quadratic, p < 0.05) crypt depth compared with the basal diet. TCE significantly increased (linear, p < 0.05) the acetic and butyric acid concentrations and decreased (quadratic, p < 0.05) the isovaleric acid concentration. Bacteroidaceae and Bacteroides, which regulate the richness and diversity of microorganisms, were more abundant and contained when TCE was added to the diet. In conclusion, these findings demonstrate that supplementing broilers with TCE could boost their immune function, antioxidant capacity, and gut health, improving their growth performance; they could also provide a reference for future research on TCE.

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“…Aging is described because the regular accumulation of organic adjustments that result in a person's practical deterioration over time (Azman and Zakaria,2019). The important frightened gadget turns into liable to oxidative strain as human beings age due to the fact their redox stability receives extra oxidized (Corzo and Silva, 2021;Lushchak, 2022;Zeng et al, 2022). In vitro improved ageing fashions consist of hydroxyurea remedy and D-galactos induction, and in vivo studies consist of radiation induction, age-improved prone mice, Klotho mice, thymus depletion, and D-galactos-brought on in vivo investigations (Mahdi et al, 2021;Wang et al, 2022;Mahdi et al, 2021;.…”

Section: Introductionmentioning

confidence: 99%

Preventive role of spirulina on the some biomarkers in heart aging induced by D- galactose on the male rabbits

Alameri

Albazi

Al-Aameli

2022

ijhs

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The aim of this study is to investigate the preventive role of food supplementation with Spirulina powder in the heart aging. Twenty male rabbits randomly and equally divided into four groups, normal as control group GI, animals received 150 mg/kg BW S/C daily of D-galactos as GII, animals were received 500mg/kg BW orally of Spirulina as GIII while GIV group was recived 150 mg/kg BW daily S/C administration of D-galactos with 500mg/kg BW orally of Spirulina for four weeks. The results of the study showed a significant decrease in Cardiac troponin I and Peroxynitrate with a significant increase in Nitric oxide and Glutathione in group received Spirulina compared with aging group GII. Conclusion, our result indicate the feed supplement of Spirulina powder caused preventive role against heart aging.

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Terminalia chebula extracts ameliorate methamphetamine-induced memory deficits via activating the ERK and Nrf2 pathway

Cited by 6 publications

References 62 publications

Alcohol Exposure Induces Depressive and Anxiety-like Behaviors via Activating Ferroptosis in Mice

Alcohol Exposure Induces Depressive and Anxiety-like Behaviors via Activating Ferroptosis in Mice

Effects of Dietary Terminalia chebula Extract on Growth Performance, Immune Function, Antioxidant Capacity, and Intestinal Health of Broilers

Preventive role of spirulina on the some biomarkers in heart aging induced by D- galactose on the male rabbits

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