Ten-Week Follow-Up of Monkeypox Case-Patient, Sweden, 2022

Pettke, Aleksandra; Filén, Finn; Widgren, Katarina; Jacks, Andreas; Glans, Hedvig; Andréasson, Sofia; Muradrasoli, Shaman; Helgesson, Sofia; Hauzenberger, Elenor; Karlberg, Maria Lind; Walai, Noura; Bjerkner, Annelie; Gourlé, Hadrien; Gredmark‐Russ, Sara; Lindsjö, Oskar Karlsson; Sondén, Klara; Asgeirsson, Hilmir

doi:10.3201/eid2810.221107

Cited by 26 publications

(41 citation statements)

References 9 publications

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“…After the removal of duplicates ( n = 566), 456 articles were screened by the authors. After filtering the titles and reading the abstracts, 85 articles were selected for full-text reading, and 65 were considered eligible for inclusion in this systematic review ( Figure 1 ) [ 18 , 20 , 21 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ,…”

Section: Resultsmentioning

confidence: 99%

“…The review included 65 studies published between 1 January and 5 October 2022. The studies ( n = 65) reported monkeypox case reports according to the specimen collection site, the number of cases, sexual behavior-oriented risk factor, history of sexually transmitted diseases, site of specimen drawn and positive for monkeypox virus by PCR, location of skin lesions, and method of diagnosis were described in detail ( Table 2 ) [ 18 , 20 , 21 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ,…”

Section: Resultsmentioning

confidence: 99%

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Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review

et al. 2022

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Due to the rapid evolution of the monkeypox virus, the means by which the monkeypox virus is spread is subject to change. Therefore, the present study aims to analyze the detection of the monkeypox virus according to the collection site of samples from confirmed monkeypox cases. A systematic literature review was performed using PubMed, Scopus, Web of Science, and Embase databases until 5 October 2022. A total of 1022 articles were retrieved using the search strategy. After removing duplicates (n = 566) and examining by title, abstract, and full text, 65 studies reporting monkeypox case reports were included with a detailed description of risk factors, sexually transmitted infections (STIs), site of monkeypox virus-positive specimens, location of skin lesions, and diagnostic test. A total of 4537 confirmed monkeypox cases have been reported, of which 98.72% of the cases were male with a mean age of 36 years, 95.72% had a sexual behavior of being men who have sex with men, and 28.1% had human immunodeficiency virus (HIV). The most frequent locations of lesions in patients diagnosed with monkeypox were: 42.85% on the genitalia and 37.1% in the perianal region. All confirmed monkeypox cases were diagnosed by reverse transcriptase polymerase chain reaction (RT-PCR), and the most frequent locations of samples collected for diagnosis that tested positive for monkeypox virus were: 91.85% from skin lesions, 20.81% from the oropharynx, 3.19% from blood, and 2.43% from seminal fluid. The disease course of the cases with monkeypox was asynchronous, with no severe complications, and most patients did not report specific treatment but simply followed a symptomatic treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review

et al. 2022

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“…However, high viral loads were detected in some rectal swabs and in urine, fecal, semen, and saliva samples at various time points after diagnosis. Noteworthy, MPXV DNA was detected in all saliva samples from the 12 cases studied by Peiró-Mestres, showing intermittent shedding [19], and was reported as detectable in saliva until 76 days after laboratory confirmation in 1 case [34].…”

Section: Human-to-human Transmissionmentioning

confidence: 99%

Human Monkeypox: Oral Implications and Recommendations for Oral Screening and Infection Control in Dental Practice

Amato

Spirito

Boccia

et al. 2022

JPM

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The World Health Organization declared the spread of the human monkeypox virus (MPXV) an “emerging threat of moderate health concern” on 23 June 2022. Although about 20,000 cases of Monkeypox (MPX) were recorded in Europe and more than 28,000 in the United States from May to October 2022, their number is still small compared to the number of dental patients treated annually. Therefore, the likelihood of oral healthcare workers encountering an MPX case is relatively low in not endemic regions. In addition, MPX-positive individuals are considered contagious only during the prodromal or acute phase. However, the exact shedding and transmission routes of MPX and the associated risk of transmission in the dental setting remain unclear. Moreover, infected subjects whose disease is confined to the head and neck may require oral and dental care because they complain of lymphadenopathy involving the cervical lymph nodes. Furthermore, MPX lesions may first appear in the oral cavity or perioral area. Therefore, given the recent spread of MPXV in non-endemic areas where dentists are not used to considering this disease in the differential diagnosis and taking appropriate preventive measures, all oral healthcare providers nowadays should be aware of the oral presentation of MPX for adequate oral screening and appropriate preventive measures for infection control in the dental practice.

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“…The confirmation of MPXV infection relies on detection of virus DNA in various body fluids. Recent studies reported the shedding of MPXV DNA in various samples [2] , [3] . However, the information of how frequently the MPXV DNA can be detected in variable clinical samples and how long it remains detectable are still very limited.…”

mentioning

confidence: 99%

“…Pettke et al reported positive PCR results in semen samples from patients who recovered from MPX for 54 d at maximum [3] . Nörz et al found the prolonged presence of MPXV DNA in rash or skin lesions and blood samples [4] .…”

mentioning

confidence: 99%