The role of peripheral blood mononuclear cells (PBMCs) in HBV intrauterine infection is not fully defined. Particularly the origin of PBMCs in HBV-infected neonates remains to be addressed. We carried out a population-based nested case-control study by enrolling 312 HBsAg-positive mothers and their babies. PBMC HBV DNA as well as serum HBsAg and HBV DNA was tested in cohort entry samples. Totally, 45.5% (142/312) of the newborns were found to be infected with HBV in perinatal transmission. 119 mother-infant pairs were identified to be different in the genetic profile of maternal and fetal PBMCs by AS-PCR and hemi-nested PCR. Among them, 57.1% (68/119) of the maternal PBMCs in index cases were positive for HBV DNA while 83.8% (57/68) of the HBV DNA positive maternal PBMCs passed the placental barrier and entered the fetus. Furthermore, maternal PBMC HBV infection was significantly associated with newborn infants HBV infection. PBMC traffic from mother to fetus resulted in a 9.5-fold increased risk of HBV infection in PBMC HBV DNA positive newborn infants. These data indicate that maternal PBMCs infected with HBV contribute to HBV intrauterine infection of newborn infants via PBMC traffic from mother to fetus.
The mechanical properties of a milled mixture of sugar cane are the basis for the establishment of a milled mixture mechanical model and the constitutive relation under different loading conditions. In this article, the static mechanical properties of the milled mixture were revealed using uniaxial confined compression, uniaxial loading‐unloading, and consolidated‐drained triaxial and direct shear tests. Axial stress is a cubic polynomial relating to the compression ratio. The Young's modulus is proportional to the loading pressure. The void ratio is exponentially related to the stress, and the compression and swelling indices are 4.273 and 0.184, respectively, in the loading‐unloading process from 0.208 to 1.389 MPa. Shear failure does not occur when the axial strain is less than or equal to 25%. Shear failure obeys the Mohr–Coulomb law, and the cohesive force and internal friction angle are 10.16 kPa and 31.5°, respectively. Other key parameters were obtained. All of these provided the basis for constructing the constitutive model of a milled mixture of sugar cane.
Practical applications
In this article, the prepared cane and bagasse are collectively called the milled mixture of sugar cane, which includes solid fiber, juice, and air. In the milling process, the three components in the milled mixture of sugar cane interact; the coupling of solid fiber and juice is particularly important. The mechanical properties of the milled mixture of sugar cane are the basis for the establishment of a milled mixture mechanical model and the constitutive relation under different loading conditions. In this article, the static mechanical properties of the milled mixture were revealed using uniaxial confined compression, uniaxial loading–unloading, and consolidated‐drained triaxial and direct shear tests. The key parameters were obtained. These rules and data improved the understanding of the stress–strain relationship of the milled mixture of sugar cane during the milling process and provided the basis for constructing the constitutive model of the milled mixture.
The general developmental patterns reported were consistent. The methodological design varied substantially. These discrepancies, however, provide insights for further systematic investigations into phonological development in Mandarin.
Source estimation of heavy metals of Hg, Cd, Zn, Pb, Ba, Bi, Sn and Sb in Xihe River sediment was studied using PCA. The results showed that there were three principal components extracted. Hg, Zn, Bi, Sn and Sb were controlled by Componet1 explaining the sources of material, chemical and pharmacy industries, Cd and Pb controlled by Component2 explaining the sources of smelting and machinery manufacturing industries and also automobile exhaust, and Ba controlled by Component3 explaining the effect of geochemical compositions changes on in the sediments. The results indicated that industry sewage and rock weathering and erosion process were the main sources of heavy metals in the Xihe River sediment.
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