Templated Open Flocs of Anisotropic Particles for Pulmonary Delivery with Pressurized Metered Dose Inhalers

Tam, Jason; Engstrom, Josh D.; Ferrer, Domingo; Williams, Robert O.; Johnston, Keith P.

doi:10.1002/jps.22091

Cited by 22 publications

(7 citation statements)

References 55 publications

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“…Itraconazole, for example, was studied in the form of nanosuspension in order to use with pMDI. (43) In this study, itraconazole (ITZ) NanoClusters were formulated in the form of dry powder for DPI applications. Micronized itraconazole as received was milled using different conditions and durations.…”

Section: Formulation Of Itraconazole (Itz)mentioning

confidence: 99%

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NanoCluster Itraconazole Formulations Provide a Potential Engineered Drug Particle Approach to Generate Effective Dry Powder Aerosols

Pornputtapitak

El-Gendy

Berkland

2015

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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Section: Formulation Of Itraconazole (Itz)mentioning

confidence: 99%

“…For example, Yang et al report itraconazole was milled for 10 days under nitrogen gas to get amorphous ITZ, (36) while Tam et al spent 2 weeks milling ITZ in water to get spherical nanoparticles. (43) Here, ITZ suspensions were collected at milling times of 0.5, 1, and 2 hours.…”

Section: Formulation Of Itraconazole (Itz)mentioning

confidence: 99%

NanoCluster Itraconazole Formulations Provide a Potential Engineered Drug Particle Approach to Generate Effective Dry Powder Aerosols

Pornputtapitak

El-Gendy

Berkland

2015

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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“…Nanosuspension technology would be an effective route to improve the stabilization of the chemical labile drugs [64]. Tam et al [67,68] have recently attempted to achieve stable nanosuspensions via a novel design of flocs structure called "open flocs. " Thin film freezing was used to produce BSA nanorods with aspect ratio of approximately 24.…”

Section: Recent Trend Of Nanosuspensionmentioning

confidence: 99%

Increasing Possibilities of Nanosuspension

Sutradhar

Khatun

Luna

2013

Journal of Nanotechnology

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Nowadays, a very large proportion of new drug candidates emerging from drug discovery programmes are water insoluble and thus poorly bioavailable. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve the solubility problems. Nano refers to particles size range of 1-1000 nm. The reduction of drug particles into the submicron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. Nanosuspensions are part of nanotechnology. This interacts with the body at subcellular (i.e., molecular) scales with a high degree of specificity and can be potentially translated into targeted cellular and tissue-specific clinical applications designed to achieve maximal therapeutic efficacy with minimal side effects. Production of drugs as nanosuspensions can be developed for drug delivery systems as an oral formulation and nonoral administration. Here, this review describes the methods of pharmaceutical nanosuspension production including advantages and disadvantages, potential benefits, characterization tests, and pharmaceutical applications in drug delivery.

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“…Much research has been done to address this problem. Beyond the use of surfactants to elevate the activation energy of agglomeration by adding electrostatic or steric barriers between particles [161,162], drug nanoparticles are also designed to reduce the interparticle attraction forces and to improve the DPI performance by blending with carrier materials, forming Trojan particles or controlled nanoparticle agglomerates [160,163].…”

Section: Metered-dose Inhalersmentioning

confidence: 99%

Routes of Delivery for Biological Drug Products

Irvine¹,

Su²,

Kwong³

2013

Pharmaceutical Sciences Encyclopedia

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Unlike conventional small‐molecule drugs, many of which can be formulated effectively with excipients to avoid degradation in the stomach and which exhibit reasonably efficient uptake through the gastrointestinal tract, biological drugs may exhibit lower stability and a greater sensitivity to enzymatic degradation, making oral delivery problematic. Thus, the majority of biologics are currently administered through subcutaneous/intramuscular injection or via intravenous infusion. Recent advances in delivery of traditional biologics include methods to increase the acceptable volume of drug solutions that can be administered subcutaneously.In addition, a number of alternative routes of administration for biologic drug products are being intensively investigated at the preclinical and clinical stages, such as intranasal, pulmonary, transcutaneous, and other routes, with some first examples of products recently licensed.This chapter will review current methods in use for marketed biologics and advanced approaches undergoing clinical testing.

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Templated Open Flocs of Anisotropic Particles for Pulmonary Delivery with Pressurized Metered Dose Inhalers

Cited by 22 publications

References 55 publications

NanoCluster Itraconazole Formulations Provide a Potential Engineered Drug Particle Approach to Generate Effective Dry Powder Aerosols

NanoCluster Itraconazole Formulations Provide a Potential Engineered Drug Particle Approach to Generate Effective Dry Powder Aerosols

Increasing Possibilities of Nanosuspension

Routes of Delivery for Biological Drug Products

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