Taurine and human spermatozoal capacitation

Chan, Sandy

doi:10.1016/0309-1651(85)90086-4

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…However, mouse spermatozoa do not need the addition of taurine to exhibit their full fertilizing ability (Fraser, 1986). Although it has been reported that human spermatozoa capacitate faster in medium with taurine added (Mortimer, 1986;Chan, 1985), their fertilizing ability in vitro does not seem to be increased by taurine (Mahadevan & Trounson, 1985).…”

Section: Introductionmentioning

confidence: 95%

Positive effect of taurine on preimplantation development of mouse embryos in vitro

Dumoulin¹,

Evers²,

Bras³

et al. 1992

Reproduction

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The effect of various taurine concentrations in modified Tyrode's medium on in vitro fertilization of mouse oocytes was examined. No significant difference in fertilization rate was found at concentrations of 0, 0.1, 1, 5, 10 and 20 mM taurine. In a second series of experiments, the effect of taurine on preimplantation embryonic development after fertilization in vitro was studied. At concentrations of 1, 5, 10 and 20 mM taurine, significantly more two-cell embryos reached the blastocyst stage compared with medium without taurine. Culture in the presence of 5 mM or 10 mM taurine resulted in blastocysts with the highest mean number of cells. The positive effect of taurine on embryonic development was found to be more pronounced both in a second medium (human tubal fluid medium) which has a higher potassium concentration than Tyrode's medium, and in a modified Tyrode's medium with an increased potassium concentration. In addition to these in vitro studies, it is reported that taurine comprised about 59% of the total free amino acid content in mouse oviduct flushings, compared with 17% in mouse serum.

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Section: Introductionmentioning

confidence: 95%

Positive effect of taurine on preimplantation development of mouse embryos in vitro

Dumoulin¹,

Evers²,

Bras³

et al. 1992

Reproduction

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“…In general, the ability of sperm to undergo a complete AR and fertilize zona-free hamster oocytes in response to several stimuli is related to fertility status and is depressed or even absent in infertile men or couples with unexplained infertility (Bolanos et al, 1983;Chan Kyono et al (1984) Lysophosphatidyl choline Ford e t al. (1991) Critser et al (1987) Aitken et al (1983) Alvarez et al (1988) Salonen (1986) Calcium ionophore A23187 ( dValue calculated by adding up its range score in three different arrangements from the highest to the lowest value of percentages of acrosome-reacted spermatozoa and differences of percentages of acrosome reaction and penetration indexes between treated and control groups.…”

Section: Resultsmentioning

confidence: 99%

Zona‐free sperm penetration assay and inducers of the acrosome reaction: A model for sperm microinjection under the zona pellucida

Tarı́n¹,

Trounson²

1993

Molecular Reproduction Devel

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In order to minimize the percentage of false-negative results in the zona-free sperm penetration assay (SPA), a wide range of substances and/or physical agents capable of inducing the acrosome reaction (AR) have been incorporated in the incubation medium. These agents can also be used for treatment of severe male infertility using the technique of sperm microinjection under the zona pellucida (SMUZ). In the present review, the percentages of acrosome-reacted spermatozoa induced by several physiological, biochemical or physical agents published in the literature are compared in order to find the most efficient method(s) of inducing the AR in human sperm as a previous requirement of optimizing the technique of SMUZ. A working estimate of the level of efficiency of a given AR inducer is calculated by adding up its range score in each of three different arrangements from the highest to the lowest value of percentages of AR and differences in percentages of AR and penetration indexes between treated and control groups in SPA. The agents able to induce the AR by nonphysiological (electropermeabilization, lysophosphatidyl choline, and freezing-thawing) have better positions in this hierarchical system than those ones which require the active participation of sperm membrane receptors or second messenger systems (progesterone, zona pellucida, and stimulators of protein kinase A). Electropermeabilization appears to be the most efficient AR inducer. However, more possibilities need to be explored to enhance the relatively low percentages of acrosome-reacted spermatozoa shown by infertile men.

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Human oviductal cells produce a factor(s) that maintains the motility of human spermatozoa in vitro

Yao

Yeung

2000

Fertility and Sterility

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Taurine and human spermatozoal capacitation

Cited by 5 publications

References 15 publications

Positive effect of taurine on preimplantation development of mouse embryos in vitro

Positive effect of taurine on preimplantation development of mouse embryos in vitro

Zona‐free sperm penetration assay and inducers of the acrosome reaction: A model for sperm microinjection under the zona pellucida

Human oviductal cells produce a factor(s) that maintains the motility of human spermatozoa in vitro

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