T3 Supraglottic Cancer: Treatment Results and Prognostic Factors

Woo, Jeong-Soo; Baek, Seung Kuk; Kwon, Soon Young; Jung, Kwang‐Yoon; Lee, Jun-Young

doi:10.1080/00016480310015713

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…In the literature, relatively few studies have addressed this issue by means of univariate and multivariate analysis. [2][3][4][5][6][7][8] For this reason, the purpose of our retrospective study was to report the oncological outcome achieved in a series of 253 consecutive patients who had undergone supracricoid partial laryngectomy (SCPL) as uniform treat-ment over a 16-year period and to determine, by means of univariate and multivariate models, a potential correlation between various prognostic factors and the oncological results. We believe that the identification of possible prognostic factors influencing oncological outcome may optimize the control of laryngeal cancer.…”

mentioning

confidence: 99%

Supracricoid Partial Laryngectomy in the Treatment of Laryngeal Cancer

Gallo¹,

Manciocco²,

Simonelli³

et al. 2005

Arch Otolaryngol Head Neck Surg

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Objectives: To evaluate the oncological results of supracricoid partial laryngectomy as a treatment for selected glottic and supraglottic cancer in a large series of patients who had undergone uniform treatment over a 16-year period and to determine the different prognostic factors that may influence local control and survival.Design: Retrospective clinical study.Setting: Academic tertiary referral medical center. Patients:The study population comprised 253 consecutive patients (234 men and 19 women) with glottic and supraglottic squamous cell carcinoma. The mean age was 58 years for men and 59.2 years for women.Intervention: Supracricoid partial laryngectomy: 180 patients had undergone cricohyoidopexy and 73 had undergone cricohyoidoepiglottopexy.Main Outcome Measures: Local control and overall survival. Potential prognostic factors for local control and survival were evaluated with univariate and multivariate models.Results: The 3-, 5-, 10-, and 16-year overall survival rates in this group of 253 patients were 85.8%, 79.1%, 57.6%, and 57.6%, respectively. With regard to local control, univariate and multivariate analyses showed that a positive resection margin was the only important predictor of local control and that a dysplastic lesion at the margin of resection is just as aggressive as the presence of invasive carcinoma. When considering the prognostic factors influencing survival, univariate analysis showed that the tumor category, lymph node category, tumor stage, and recurrence all had a significant influence on the survival rate. Multivariate analysis showed that the most important predictor of survival was recurrence.Conclusions: Supracricoid partial laryngectomy is a valid choice in the treatment of selected glottic and supraglottic cancer while maintaining laryngeal functions and achieving a high rate of local control. T category, N category, tumor stage, positive resection margins, and recurrence are the most important predictors of oncological outcome.

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confidence: 99%

Supracricoid Partial Laryngectomy in the Treatment of Laryngeal Cancer

Gallo¹,

Manciocco²,

Simonelli³

et al. 2005

Arch Otolaryngol Head Neck Surg

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“…Of the 176 full-text articles assessed for eligibility, 169 were excluded because they were epidemiological studies and because specific survival data for T3N+ could not be retrieved or was merged with other stages. In total, 6 studies [20][21][22][23][24][25] were included ( Figure 3, Table 3). All studies were retrospective.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…One article [23] was excluded from the mean calculation because the 3-year OS was only reported. The mean OS could not be calculated in the T4N0 subgroup because of insufficient data:…”

Section: Clinical Data and Outcomementioning

confidence: 99%

Survival of T4aN0 and T3N+ laryngeal cancer patients: a retrospective institutional study and systematic review

Khoueir

Matar

Farah

et al. 2015

American Journal of Otolaryngology

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“…A combination oncologic, quality of life and laryngeal function factors all contribute to the healthcare team and patient’s decision on treatment modality. Multiple possible treatments exist including radiation with or without chemotherapy, total laryngectomy, open partial laryngectomy or transoral laser microsurgery [28–32]. Despite these data, there are no recommendations available for treating laryngeal, specifically supraglottic cancer in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Management across the laryngeal cancer in pregnancy case reports found in our literature search were variable ranging from total laryngectomies during pregnancy to radiotherapy following delivery [22, 28]. In the case report of the other supraglottic squamous cell carcinoma a tracheostomy and complete excision with carbon dioxide laser was completed [14].…”

Section: Discussionmentioning

confidence: 99%

Supraglottic p16+ squamous cell carcinoma during pregnancy: a case report and review of the literature

Pugi

Levin

Gupta

2019

J of Otolaryngol - Head & Neck Surg

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Background Head and neck cancer during pregnancy is uncommon. Specifically, laryngeal cancer in pregnancy has only been previously reported 10 times. HPV p16+ supraglottic cancer during pregnancy has never been described in the literature prior to this case report. This case is important to report to understand the most effective and safe diagnostic, treatment and follow-up options available for pregnant patients with laryngeal cancer. Case presentation This report describes a case of a 33-year-old patient who was 24 weeks pregnant presenting with dysphonia and odynophagia. After laryngeal biopsy and MRI she was diagnosed with T3N1M0, stage three p16+ squamous cell carcinoma of the supraglottis. After inter-disciplinary consultation as well as extensive patient discussion, an awake tracheostomy, PEG tube placement and then elective C-section at 28 weeks’ gestation was completed. This was followed by chemoradiotherapy. The patient has remained free from disease with a healthy child at four years post-treatment. Conclusion Supraglottic cancer during pregnancy is rare with only four previous cases reported in the literature. This case report elucidates the importance of including multiple specialities as well as patient preference in the decision-making process regarding treatment for patients with supraglottic cancer during pregnancy. Furthermore, diagnostic and treatment guidelines for pregnant patients with head and neck cancers should be established to promote the best possible oncological, obstetrical and neonatal care.

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T3 Supraglottic Cancer: Treatment Results and Prognostic Factors

Cited by 5 publications

References 7 publications

Supracricoid Partial Laryngectomy in the Treatment of Laryngeal Cancer

Supracricoid Partial Laryngectomy in the Treatment of Laryngeal Cancer

Survival of T4aN0 and T3N+ laryngeal cancer patients: a retrospective institutional study and systematic review

Supraglottic p16+ squamous cell carcinoma during pregnancy: a case report and review of the literature

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