Survival of T4aN0 and T3N+ laryngeal cancer patients: a retrospective institutional study and systematic review

Khoueir, Nadim; Matar, Nayla; Farah, Chadi; Francis, Evana; Tabchy, Bassam; Haddad, A.

doi:10.1016/j.amjoto.2015.07.009

Cited by 13 publications

(16 citation statements)

References 31 publications

(43 reference statements)

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“…The disease is accounted for approximately 30 to 40 percent of all head and neck malignancies and 1 to 2.5 percent of all malignancies in the human body [ 2 , 3 ]. In terms of gender, it is the eleventh most common cancer in men during middle age [ 4 ]. LC mostly involves the glottic area [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Treatment Strategies and Tumor Stage on Survival of Patients with Advanced Laryngeal Carcinoma: A 15-Year Cohort Study

Daneshi¹,

Fararouei

Mohammadianpanah

et al. 2018

Journal of Cancer Epidemiology

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Background Laryngeal cancer is the second most common cancer in the head and neck. Since laryngeal cancer management is a complex process, there is still no standard strategy to treat this disease in order to increase the survival rate of the patients especially among those with advanced form of the disease. Methods A cohort study was undertaken to analyze factors predicting survival of the patients in advanced stage laryngeal cancer in the Southern Iran among all patients newly diagnosed with laryngeal cancer between 2000 and 2015. Results Data of a total number of 415 patients who have had been diagnosed with advanced laryngeal cancer during this period was used for analysis. The patients' 1-, 3-, 5-, and 10-year survival rates were 81%, 62%, 53%, and 38%, respectively. Multivariable Cox regression analyses indicated a significant relationship between patients' survival and age at diagnosis (P < 0.001), disease stage (P = 0.002), tumor grade (P = 0.008), positive L. node (P = 0.008), and type of treatment (P < 0.001). As expected, treatment strategy was identified as the most effective factor in survival of the patients. According to the results, patients who undergone surgical treatment experienced a longer survival than those who received other treatments. Conclusion This study showed that the survival of patients depends on several factors, among which, treatment strategy is the most important. Combination of total laryngectomy plus chemoradiation provides superior local control and better survival compared to either radiotherapy or chemoradiation in patients with advanced laryngeal cancer.

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Section: Introductionmentioning

confidence: 99%

Effects of Different Treatment Strategies and Tumor Stage on Survival of Patients with Advanced Laryngeal Carcinoma: A 15-Year Cohort Study

Daneshi¹,

Fararouei

Mohammadianpanah

et al. 2018

Journal of Cancer Epidemiology

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“…In their study, Khoueir et al stated that lymph node involvement affects the survival more than T stage. 10 If cervical lymph node metastasis is ignored, the number of patients with poor prognosis due to postoperative regional recurrence or distant metastasis may increase greatly. [11][12][13] In our study, while 2-year OS rate was 66.7% in patients without lymph node metastasis in neck, it was 46.2% in patients with lymph node metastasis without ENE.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Extranodal Extension on Survival in Laryngeal Carcinoma

Bulğurcu¹,

İdil²,

Küçük³

et al. 2019

Ear Nose Throat J

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It is known that lymph node metastasis lowers the survival rates in laryngeal carcinoma. This study aimed to investigate the effect of extranodal extension in lymph node metastasis on survival. The demographic characteristics and histopathologic results of 81 patients who underwent total laryngectomy and neck dissection due to advanced larynx squamous cell carcinoma between 2011 and 2018 were reviewed retrospectively. The patients were divided into 3 groups by lymph node metastasis status as reactive lymph node (group 1), lymph node metastasis without detected extranodal extension (group 2), and lymph node metastasis with detected extranodal extension (group 3). Survival analysis was performed between these 3 groups. In the patient population with a mean age of 61.56 years consisting of 6 females and 75 males, demographic characteristics between groups were comparable. Overall survival (OS) rates were detected to be 81% in group 1, 69.2% in group 2, and 61.5% in group 3. Two-year OS rates were detected to be 66.7% in group 1, 46.2% in group 2, and 38.5% in group 3. Statistical difference was detected between group 1 and group 3 both for OS and 2-year OS ( P = .014, P = .008, respectively). No statistical difference was detected between group 2 and group 1, and between group 2 and group 3. In this study, we found a negative effect of detecting neck lymphadenopathy metastasis and extranodal extension on survival in patients who underwent total laryngectomy and neck dissection due to advanced laryngeal carcinoma.

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“…A recent meta-analysis indicated that a 5-year overall survival rate of LSCC patients is lower than 64.3% (4). Another study revealed a 5-year overall survival for the T3N+ stage of LSCC of 33% (5). Therefore, more advanced and effective treatments and diagnostic methods for LSCC are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA 103862 Promotes Proliferation and Invasion of Laryngeal Squamous Cell Carcinoma Cells Through the miR-493-5p/GOLM1 Axis

Wang

et al. 2020

Front. Oncol.

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Accumulating evidence suggests that circular RNAs (circRNAs) may be a key contributor to oncogenesis. Yet, the function of circRNAs in laryngeal squamous cell carcinoma (LSCC) is still not clear. In this study, we examined the function of circRNA_103862 in LSCC progression by analyzing the tissue specimens collected from a patient with LSCC by using different LSCC cell models in vitro and an LSCC xenograft model in nude mice. We found that circRNA_103862 was frequently upregulated in the tissues of LSCC and was correlated with metastasis and prognosis of LSCC patients. Furthermore, circRNA_103862 downregulation could reduce proliferation, migration, and invasion ability of LSCC cells. In terms of mechanism exploration, miR-493-5p was sponged by circRNA_103862. Rescue experiments also showed that circRNA_103862 could achieve a carcinogenic effect by regulating miR-493-5p. Moreover, a luciferase reporter analysis showed that Golgi membrane protein 1 (GOLM1) is a downstream effector of miR-493-5p. In conclusion, our data suggested that circRNA_103862 promotes the proliferation of LSCC through targeting the miR-493-5p/GOLM1 axis, and it might serve as a potential prognosis marker and therapy target for LSCC.

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Survival of T4aN0 and T3N+ laryngeal cancer patients: a retrospective institutional study and systematic review

Cited by 13 publications

References 31 publications

Effects of Different Treatment Strategies and Tumor Stage on Survival of Patients with Advanced Laryngeal Carcinoma: A 15-Year Cohort Study

Effects of Different Treatment Strategies and Tumor Stage on Survival of Patients with Advanced Laryngeal Carcinoma: A 15-Year Cohort Study

The Effect of Extranodal Extension on Survival in Laryngeal Carcinoma

Circular RNA 103862 Promotes Proliferation and Invasion of Laryngeal Squamous Cell Carcinoma Cells Through the miR-493-5p/GOLM1 Axis

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