Supracricoid Partial Laryngectomy in the Treatment of Laryngeal Cancer

Abstract

Objectives: To evaluate the oncological results of supracricoid partial laryngectomy as a treatment for selected glottic and supraglottic cancer in a large series of patients who had undergone uniform treatment over a 16-year period and to determine the different prognostic factors that may influence local control and survival.Design: Retrospective clinical study.Setting: Academic tertiary referral medical center. Patients:The study population comprised 253 consecutive patients (234 men and 19 women) with glottic and supraglottic squamous cell carcinoma. The mean age was 58 years for men and 59.2 years for women.Intervention: Supracricoid partial laryngectomy: 180 patients had undergone cricohyoidopexy and 73 had undergone cricohyoidoepiglottopexy.Main Outcome Measures: Local control and overall survival. Potential prognostic factors for local control and survival were evaluated with univariate and multivariate models.Results: The 3-, 5-, 10-, and 16-year overall survival rates in this group of 253 patients were 85.8%, 79.1%, 57.6%, and 57.6%, respectively. With regard to local control, univariate and multivariate analyses showed that a positive resection margin was the only important predictor of local control and that a dysplastic lesion at the margin of resection is just as aggressive as the presence of invasive carcinoma. When considering the prognostic factors influencing survival, univariate analysis showed that the tumor category, lymph node category, tumor stage, and recurrence all had a significant influence on the survival rate. Multivariate analysis showed that the most important predictor of survival was recurrence.Conclusions: Supracricoid partial laryngectomy is a valid choice in the treatment of selected glottic and supraglottic cancer while maintaining laryngeal functions and achieving a high rate of local control. T category, N category, tumor stage, positive resection margins, and recurrence are the most important predictors of oncological outcome.

Modified supracricoid laryngectomy: oncological and functional outcomes in the elderly

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Benefits and drawbacks of open partial horizontal laryngectomies, Part A: Early‐ to intermediate‐stage glottic carcinoma

“…Our data show that the outstanding oncologic outcomes obtained by open partial horizontal laryngectomy reproduced by other authors 28,29 justify the open-neck procedures in terms of local control, particularly in selected pT3 lesions. In fact, in this cohort, any variables analyzed have shown a negative impact on the endpoints evaluated.…”

Evidence and evidence gaps of laryngeal cancer surgery

“…A patient population of 253 patients revealed survival rates after 3, 5, 10, and 16 years after supracricoid partial resection for glottic and supraglottic carcinomas of 85.8%, 79.1%, 57.6%, and 57.6%, respectively [97]. These data are confirmed by other studies that described 5-year survival rates of 66-88% [98], [99], [100], [101], [102], [103], [104]. Organ preservation is mostly possible.…”