Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

Abstract

Many synthetic drugs reported to be used for the treatment of inflammatory disorders are of least interest now a days due to their potential side effects and serious adverse effects and as they are found to be highly unsafe for human assistance. Since the last few decades, herbal drugs have regained their popularity in treatment against several human ailments. Herbals containing anti-inflammatory activity (AIA) are topics of immense interest due to the absence of several problems in them, which are associated with synthetic preparations. The primary objective of this review is to provide a deep overview of the recently explored anti-inflammatory agents belonging to various classes of phytoconstituents like alkaloids, glycosides, terpenoids, steroids, polyphenolic compounds, and also the compounds isolated from plants of marine origin, algae and fungi. Also, it enlists a distended view on potential interactions between herbals and synthetic preparations, related adverse effects and clinical trials done on herbals for exploring their AIA. The basic aim of this review is to give updated knowledge regarding plants which will be valuable for the scientists working in the field of anti-inflammatory natural chemistry.

Radiographic and Histopathologic Analysis on Osteoarthritis Rat Model Treated with Essential Oils of Rosmarinus officinalis and Populus alba

“…3 Indeed, several of the medicinal plants grown worldwide are well known for their essential oil (EO) which are aromatic, antimicrobial and possess curative potential against different diseases including osteoarthritis (OA) and other inflammatory conditions. 4,5 Accordingly, Rosmarinus officinalis L. (Lamiaceae) and Populus alba L. (Salicaceae) were selected as essential oil bearing plants for the present study. We seek first to study the acute toxicity of essential oils of Rosemary and white poplar.…”

Ayurvedic, Phytochemical and Pharmacological Review of Schleichera Oleosa (Lour.) Oken: A Traditional Plant With Enormous Biological Activity

“…Alkaloids, glycosides, terpenoids, resins, phenolic compounds, flavonoids, steroids, fatty acids are the responsible phytoconstituents for the anti-inflammatory activity in plants. [27] The bark of the plant contains tannin, and therefore, the possible mechanism of the bark extract to exert the activity by scavenging free radicals like nitric oxide (NO antiulcer activity against animal model. [28] Tannins, which are mainly used in medicine for their astringent property, has the property to protect at the site of ulcer by precipitating microproteins and provide resistance against the mechanical injury and proteolytic enzymes.…”

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

“…Inflammation is a complex phenomenon. Several components such as edema formation, leukocyte infiltration and granuloma formation are elicited in response to an inflammatory reaction (Beg et al, 2011). In inflammation, several potent chemical mediators such as prostaglnadins, leukotrienes, prostacyclins, lymphokines and chemokines like Interferon-α (IFN-α), γ, Interleukin (IL)-1, IL-8, histamine, 5-Hydroxytryptamine (5-HT) and tissue necrosis factor-α are released in the inflamed tissues (Serhan and Savill, 2005).…”

“…On the other hand plant derived preparations are gaining much importance in therapeutical applications because they are cheap, easily available and have little side effects. Thus, the use of traditional medicine and medicinal plants in most developing countries has been widely observed for the treatment of various ailments including prevention and management of pain, inflammation and other oxidative stress associated diseases such as cancer, atherosclerosis, aging and neurodegenerative disorders (Beg et al, 2011;Jain et al, 2014).…”