Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde

Cui, Yuming; Dong, Xiongwei; Li, Yuguang; Li, Zuowen; Chen, Wu

doi:10.1016/j.ejmech.2012.09.037

Cited by 63 publications

(17 citation statements)

References 34 publications

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“…The results indicate that the inhibitory efficiency of the complex towards urease may be influenced by the transition metal and ligands, and the inhibitory activity probably is due to strong Lewis acid properties of copper ions and the ligands strengthen the inhibitory activity of the complexes. The results are in accord with those reported previously, where some Cu(II) complexes have stronger urease inhibitory activities to urease than their parent ligands and metal ion, with IC 50 ranging from 1 to 50 μM [15,28,[35][36][37][38][39]. Compared with the data reported before, the complexes reported in this study exhibit fairly strong inhibitory activity to urease and may be used as urease inhibitors.…”

Section: Resultssupporting

confidence: 95%

Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

Sheng

Zhou

Sun

et al. 2014

Journal of Coordination Chemistry

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3), with a ligand derived from protocatechuic acid (HL 1 = C 9 H 8 O 4 =2,3-dihydrobenzo[b][1,4]-dioxine-6-carboxylic acid, L 2 = C 7 H 9 N=o-toluidine, L 3 = C 6 H 16 N 2 =N,N-diethylethylenediamine) were synthesized and characterized by C, H, and N elemental analysis and single-crystal X-ray diffraction, which revealed that the three complexes have similar binuclear structures. Complexes 1 and 3 crystallized in triclinic space group P-1 and 2 in orthorhombic space group P2 1 2 1 2 1 . The urease inhibitory activities of the three complexes were tested. All three complexes showed strong inhibitory activity against jack bean urease with an IC 50 value of 6.8, 5.5, and 3.5 μM compared with the acetohydroxamic acid (IC 50 = 7.5 μM), which was a positive control.

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Section: Resultssupporting

confidence: 95%

Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

Sheng

Zhou

Sun

et al. 2014

Journal of Coordination Chemistry

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“…Owing to their very flexible and variable structural characteristics, multiple Schiff bases and their complexes have been synthesized and studied. It is possible to use Schiff bases in many biological applications [14,[23][24][25][26]. They are considered as an important class of organic compounds.…”

Section: Introductionmentioning

confidence: 99%

“…They are considered as an important class of organic compounds. Some Schiff bases have been reported to possess antibacterial, antifungal, anticarcinogenic, anticonvulsant, antituberculosis, antioxidant, antimalarial, antiflammatory, anticorrosive, anti-HIV, and antitumor activities [14,[23][24][25][26][27][28][29][30]. When Schiff bases used as inhibitors were analyzed, their inhibitory effects were observed to vary by the type of functional groups attached to the benzene ring in the structure, if these bases contained aryl substituents [31,32].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of Some Optically Active Imine Compounds on the Enzyme Activities of hCA‐I and hCA‐II under In Vitro Conditions: An Experimental and Theoretical Study

Tektas

Akkemik

Baykara

2016

J Biochem & Molecular Tox

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Inhibitors of carbonic anhydrase (hCA; EC 4.2.1.1) are used as medicines for many diseases. Therefore, they are very important. In this study, a known series of Schiff bases were synthesized and their effects on the activities of hCA-I and hCA-II, which are cytosolic isoenzymes of carbonic anhydrase, were investigated under in vitro conditions. The synthesized compounds (H1, H2, H3, and H4) were found to cause inhibition on enzyme activities of hCA-1 and hCA-II. IC50 values of H1, H2, H3, and H4 compounds were 140, 88, 201, and 271 μM for hCA-I enzyme activity and 134, 251, 79, and 604 μM for hCA-II enzyme activity, respectively. The synthesized Schiff bases were characterized by several methods, including (1) H NMR, FT-IR, elemental analysis, and polarimetric measurements. Correlation coefficient square values (R(2) ) of comparison of the theoretical and experimental (1) H NMR shifts for H1, H2, H3, and H4 compounds were found as 0.9781, 0.9814, 0.9758, and 0.8635, respectively.

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“…They were assigned to NH(1) and OH(2) proton respectively. Both peaks were strongly de-shielded due to direct attachment to high electro negative atoms (Cui et al, 2012; Webster and Silver stein, 2006). The doublet signal at d = 9.13 ppm, and doublet of doublet signal at d = 8.83 ppm were attributed to H(3) and H(4) respectively.…”

Section: Synthesis Of Ni(ii) Complexes Of (E)-n'-(5-chloro-mentioning

confidence: 99%

“…The solution was refluxed for 4 h and te precipitate formed was allowed to stand at ambient temperature for 12 h after which it was filtered, washed and dried over P 4 (Figure 1.0) in DMSO-d6showed singlet peaks at d = 12.36 ppm and d = 11.21 ppm. They were assigned to NH(1) and OH(2) proton respectively.…”

Section: Synthesis Of Ni(ii) Complexes Of (E)-n'-(5-chloro-mentioning

confidence: 99%

Structural and Biological Activity Study of (E)-N’- (5-Chloro-2-Hydroxybenzylidene)Nicotinohydrazide) [H2L] and some of its Divalent Metal Complexes

Olurotimi¹,

Adeyemi²,

Agbeke³

et al. 2017

Orient. J. Chem

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Nicotinic acid hydrazide and 2-hydroxyl-5-chlorobenzaldehyde were condensed at 80 o C to form an ONO coordination pattern ligand (H 2 L). The structure of the ligand was elucidated by using 1 H NMR, 13C NMR, COSY, HSQC, CHN analyzer, ESI mass spectrometry and IR, Thereafter, five metal complexes [Cu(II), Fe(II), Zn(II), Mn(II) and Ni(II)] of the ligand were synthesized and their structural elucidation were achieved by using elemental analysis, infrared, EPR, molar conductivity and powder X-ray diffraction studies. Structural geometries of some of the compounds were predicted. Based on the analysis, octahedral geometry was suggested for the complexes. In vitro anti tubercular activity study of the ligand and the metal complexes were evaluated against Mycobacterium tuberculosis, H37Rv, by using micro-diluted method. The results obtained (H 2 L-MIC = 0.86 µg/mL), (CuL-MIC = 0.64 µg/mL), (FeL-MIC = 0.77 µg/mL), (ZnL-MIC = 0.69 µg/mL), (MnL-MIC = 1.12 µg/mL) and (NiL-MIC = 0.92 µg/mL) revealed that all the compounds except (MnL-MIC = 1.12 µg/mL) possess better activity when compared with one of the first line drug (isoniazid) (INH-MIC = 0.9 µg/mL). H 2 Lexhibited higher anti tubercular activity with MIC value of 0.86 µg/mL. However, the metal complexes displayed higher cytoxicity but were found to be non-significant different (P < 0.05) to is on isoniazid drug.

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Synthesis, structures and urease inhibition studies of Schiff base metal complexes derived from 3,5-dibromosalicylaldehyde

Cited by 63 publications

References 34 publications

Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

Investigation of the Effect of Some Optically Active Imine Compounds on the Enzyme Activities of hCA‐I and hCA‐II under In Vitro Conditions: An Experimental and Theoretical Study

Structural and Biological Activity Study of (E)-N’- (5-Chloro-2-Hydroxybenzylidene)Nicotinohydrazide) [H2L] and some of its Divalent Metal Complexes

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