Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

Abstract

3), with a ligand derived from protocatechuic acid (HL 1 = C 9 H 8 O 4 =2,3-dihydrobenzo[b][1,4]-dioxine-6-carboxylic acid, L 2 = C 7 H 9 N=o-toluidine, L 3 = C 6 H 16 N 2 =N,N-diethylethylenediamine) were synthesized and characterized by C, H, and N elemental analysis and single-crystal X-ray diffraction, which revealed that the three complexes have similar binuclear structures. Complexes 1 and 3 crystallized in triclinic space group P-1 and 2 in orthorhombic space group P2 1 2 1 2 1 . The urease inhibitory activities of the three complexes were tested. All three complexes showed strong inhibitory activity against jack bean urease with an IC 50 value of 6.8, 5.5, and 3.5 μM compared with the acetohydroxamic acid (IC 50 = 7.5 μM), which was a positive control.

Synthesis, Characterization, DNA Binding and Cytotoxicity of Copper(II) Phenylcarboxylate Complexes

“…In C3, the Cu•••Cu distance is 2.5787(5) Å, also contained in the expected range. The same intermetal distance was observed in the structures with hexanoate [44], benzoate [45,46] and 2,3-dihydro-1,4-benzodioxine-6-carboxylate [47]. C-H•••π interactions can be observed between phenyl rings of ligands within the paddle wheel on the 1D chain contiguous molecules with a centroid to H distance of 3.062 Å and an angle between the phenyl rings of 71.00 • .…”