Synthesis, Reactions, and Pharmacological Screening of Heterocyclic Derivatives Using Nicotinic Acid as a Natural Synthon

Abstract

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Pharmacological activities of some new polycyclic triazolopyrazolopyridazine derivatives

“…In addition, we reported that certain of our newly substituted heterocyclic compounds exhibited antiparkinsonian [21], antitumor [22][23][24], antimicrobial [25] and anti-inflammatory [26] activities. Recently, some new substituted heterocyclic derivatives have been synthesized [27], which exhibit antimicrobial [28,29], analgesic, antiinflammatory and activities [30][31][32][33][34][35]. In view of these observations and as continuation of our previous works in heterocyclic chemistry, we have herein synthesized some new poly heterocyclic fused ring systems containing pyrazole nuclei, and tested their antiinflammatory, analgesic and antimicrobial activities in comparison to indonethacin, valdoxib, tertacycline, ketoconazole, bleomycin, gallic acid as positive controls.…”

Synthesis of some New Dihydropyrimidines Derivatives by Cyclization of Polarized Unsaturated Systems

“…The pyrimidinethione possess relevant pharmacological activity, and the development of optimal synthetic methods for some of their classes is of interest . Recent studies reported the synthesis of some new fused thiooxopyrimidine candidates which showed antimicrobial , anticonvulsant , antiarrhythmic , anti‐inflammatory , and antitumor activities . Some pyrimidine thione derivatives were prepared by condensation of thiourea with the appropriate aromatic aldehyde and acetyl acetone based on the previously reported similar methods .…”

Direct Synthesis of Trichloro‐thiazolo[3,2‐a]pyrimidine and Thiazolo[2,3‐b]quinazoline Derivatives

“…Thiazolo[3,2‐ a ]pyrimidines, thiazolo[3,2‐ a ]pyrimidinones, and their derivatives have emerged as molecules with potentially useful therapeutic properties that have gained considerable attention from both synthetic and medicinal chemists due to their vital role in many biological activities such as antiinflammatory , antioxidant , antimicrobial , anticancer , antitumor , anticonvulsant , antiparkinsonian , antinociceptive , and antiviral . Such compounds have also been reported as 5‐hydroxytryptamine 2 receptor antagonists and inhibitors of xanthine oxidase , CDC25B phosphatase enzymes , and the Bcl‐2 family of proteins .…”