Direct Synthesis of Trichloro‐thiazolo[3,2‐a]pyrimidine and Thiazolo[2,3‐b]quinazoline Derivatives

Abstract

in Wiley Online Library (wileyonlinelibrary.com).An efficient one-pot method for synthesis of new biologically active thiazolo[3,2-a]pyrimidine and thiazolo[2,3-b]quinazoline derivatives is described via reaction of pentachloropyridine with fused pyrimidine-2(5H)-thiones or quinazoline-2(1H)-thiones. These reactions were carried out in the presence of potassium carbonate as a base in acetonitrile as a solvent to produce products 3a-n in good-toexcellent yield. Pentachloropyridine is doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidine and thiazolo[2,3-b]quinazoline products.Scheme 2. A plausible mechanism for synthesis of the fused thiazolo[3,2-a]pyrimidines and thiazolo[2,3-b]quinazolines.