Synthesis of some New Dihydropyrimidines Derivatives by Cyclization of Polarized Unsaturated Systems

Ragab, Islam; Selim, Yasser; El‐Azim, Mohamed H. M. Abd

doi:10.1002/jhet.3332

Cited by 2 publications

References 17 publications

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Cyclization of thiosemicarbazide derivative: As a source of novel synthesis of some azoles and azines

El‐Azim

Assy

Selim

2020

Journal of Heterocyclic Chem

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In our study, we aimed to synthesize novel, some biologically active compounds, Azoles and Azines derivatives, that to be nitrogen‐containing heterocycles, and have their diverse therapeutic values. Thiosemicarbazide, 2, was obtained from the attack of nitrogen of hydrazine to the carbon of heteroallene function of compound 1. Triazolotriazole derivative, 4, was obtained from the reaction of 2 with diethyl malonate. Cyclization of thiourea unit of compound 2 with heteroallene, 1, gave trazine, 6. Benzolyation of 2 using benzoyl chloride formed triazole derivative, 8. Reaction of 2 and maleic anhydride gave furothiadazine, 10. Cyclohexanopyrimidinthione, 12, was obtained from cyclocondensation of cyclohexanone with 2. Triazole, 14, was obtained from 2 and ammonium isothiocynate under thermal condition. Reaction of 2 with ethyl bromoacetate gave thiazole derivative, 16. [2+3] Cyclocondensation of acetyl acetone with 2 provided pyrazole, 18. Triazolotriazole, 20, was obtained from formalin and 2. Compound 2 suffers intramolecular base mediated cyclization affording pyrazole, 21. Keeping 2 and propinaldehyde under reflux provided triazolotriazole, 24. Acylation of 2 by succinic acid formed pyridazine derivative, 27.

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