Synthesis of potential anticancer agents—I

Gogte, V. N.; Shah, Lubna; Tilak, B. D.; Gadekar, K.N.; Sahasrabudhe, M. B.

doi:10.1016/0040-4020(67)80079-6

Cited by 70 publications

(29 citation statements)

References 4 publications

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“…Although several routes towards EDT (5) are possible, Jonas et al developed a synthetic strategy, shown in Scheme 1, starting from thiodiglycolic acid, based on the synthesis of 3,4-ethylenedioxythiophene-2,5-dicarboxylic acid (4) reported by Gogte et al [13] Subsequent decarboxylation using a copper salt led to EDT in five steps. [9,14] EDT has a boiling point of 225 C (1013 mbar) and slowly turns dark upon exposure to air and light due to partial oxidation.…”

Section: 4-ethylenedioxythiophene and Related Substituted Derivativesmentioning

confidence: 99%

Poly(3,4-ethylenedioxythiophene) and Its Derivatives: Past, Present, and Future

et al. 2000

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An overview of one of the most successful conducting polymers, poly(3,4-ethylenedioxythiophene) (PEDT) and its derivatives, is presented, detailing its early development, the synthesis of numerous hybrid and derivative materials, along with a description of the broad array of properties accessible and a description of a set of the more prominent applications in which they can be utilized. Synthetic flexibility and facility is the key to the many new 3,4-ethylenedioxythiophene-(EDT-) based monomers, oligomers, and (co)polymers. These (co)polymers provide highly conducting and especially stable doped states, a range of optical properties with electronic bandgaps varying across the entire visible spectrum, and enhanced redox properties, making them useful for numerous electrochemical devices. Present and future applications for PEDT that are discussed include static charge dissipation films and electrode materials in solid electrolyte capacitors.

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Section: 4-ethylenedioxythiophene and Related Substituted Derivativesmentioning

confidence: 99%

Poly(3,4-ethylenedioxythiophene) and Its Derivatives: Past, Present, and Future

et al. 2000

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“…The key starting materials 2 and 3 were obtained using two methods as reported previously. [19,20] Hydrolysis of these compounds under basic conditions followed by subsequent acidification afforded dicarboxylic acids 4. Thereafter, treatment of 4 with thionyl chloride to afford reactive acid chlorides and subsequent reaction with hydrazine hydrate in NMP at 0 8C afforded the precursor polyhydrazides 5.…”

Section: Methodsmentioning

confidence: 99%

The Synthesis and Characterisation of Fluorescent Poly(heteroaromatic oxadiazole)s

Ding

Chan

et al. 2001

Macromol. Chem. Phys.

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“…S -(10-undecen-1-yl)isothiouronium iodide was found to be effective against Walker carcinoma cells in rats (Carmona and Gonzalez-Cadavid, 1978; Gonzalez-Cadavid and Herrera Quijada, 1974), and bisisothiouronium derivatives of thiophene were reported to show activity against Yoshida sarcoma (Gogte et al ., 1967). Recently, a report showing proapoptotic activity of a number of pentabromobenzylisothiourea derivatives with substantial cytotoxicity toward human glioblastoma cells has been published.…”

Section: Introductionmentioning

confidence: 99%

Proapoptotic effects of novel pentabromobenzylisothioureas in human leukemia cell lines

2011

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A series of new pentabromobenzylisothioureas [ZKK-1–ZKK-5; (ZKKs)] carrying additional substituents on nitrogen atoms has been synthesized. The ZKKs were found to induce apoptosis in HL-60 (human promyleocytic leukemia) and K-562 (human chronic erythromyeloblastoid leukemia) cell lines in a concentration-dependent manner at low micromolar concentrations. ZKK-3 [(N,N′-dimethyl-S-2,3,4,5,6-pentabromobenzyl)isothiouronium bromide] showed the highest proapoptotic activity in HL-60 cells, whereas ZKK-2 [N-methyl-S-(2,3,4,5,6-pentabromobenzyl)isothiouronium bromide] was most effective in this respect in K-562 cells. During the ZKKs-induced apoptosis, an 85 kDa fragment of cleaved PARP (caspase-3 and caspase-7 substrate) was detected in both cell lines tested. The studied compounds also decreased mitochondrial transmembrane potential in both these cell lines and caused the cells to accumulate in G1 and at the G1/S border of the cell cycle in a concentration-dependent manner. These results show promise for their study as new compounds in the treatment of leukemia, after an appropriate preclinical toxicity profile.

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Synthesis of potential anticancer agents—I

Cited by 70 publications

References 4 publications

Poly(3,4-ethylenedioxythiophene) and Its Derivatives: Past, Present, and Future

Poly(3,4-ethylenedioxythiophene) and Its Derivatives: Past, Present, and Future

The Synthesis and Characterisation of Fluorescent Poly(heteroaromatic oxadiazole)s

Proapoptotic effects of novel pentabromobenzylisothioureas in human leukemia cell lines

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