Alitcim!-cin C ( l a ) was converted hy acid hydrulysis to a series of degradation products (Ha-f, IIIa and b).Ozonization, reduction, and oxidation react'ions were carried out with selected acid hydrolysis products to establish the carhon skeleton. Comparative acid hydrolysis studies of Ia and N-methylmitomycin (porfiromycin) (Ib) together with pK,' and n.m.r. data, indicated the presencae and location of t,he aziridine ring. Deuterium incorporation studies showed that. the methoxyl group in mitomycin C was located at position Ya. The structure fur mitomycin C deduced in this investigation is in agreement with that reported in the recent communication of the Lederle workers*& and the X-ray analysis.2bsoc., 81, 4632 (1960).( 8 ) V.
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