Synthesis of Plasmin‐Loaded Fe3O4@CaCO3 Nanoparticles: Towards Next‐Generation Thrombolytic Drugs

Serov, Nikita; Prilepskii, Artur Y.; Sokolov, A. V.; Vinogradov, Vladimir V.

doi:10.1002/cnma.201900359

Cited by 12 publications

(9 citation statements)

References 43 publications

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“…MNPs are already widely used both as a drug and contrast agent for MRI [56], and vaterite is a native component of the human organism which undergoes biotransformation [57]. The magnetically-controlled vaterite matrix was considered to have low toxicity based on the previously obtained cytotoxicity and cellular uptake data [58].…”

Section: Discussionmentioning

confidence: 99%

Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication

Rumyantceva

Andreeva

et al. 2021

IJMS

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Biofilms are the reason for a vast majority of chronic inflammation cases and most acute inflammation. The treatment of biofilms still is a complicated task due to the low efficiency of drug delivery and high resistivity of the involved bacteria to harmful factors. Here we describe a magnetically controlled nanocomposite with a stimuli-responsive release profile based on calcium carbonate and magnetite with an encapsulated antibiotic (ciprofloxacin) that can be used to solve this problem. The material magnetic properties allowed targeted delivery, accumulation, and penetration of the composite in the biofilm, as well as the rapid triggered release of the entrapped antibiotic. Under the influence of an RF magnetic field with a frequency of 210 kHz, the composite underwent a phase transition from vaterite into calcite and promoted the release of ciprofloxacin. The effectiveness of the composite was tested against formed biofilms of E. coli and S. aureus and showed a 71% reduction in E. coli biofilm biomass and an 85% reduction in S. aureus biofilms. The efficiency of the composite with entrapped ciprofloxacin was higher than for the free antibiotic in the same concentration, up to 72%. The developed composite is a promising material for the treatment of biofilm-associated inflammations.

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Section: Discussionmentioning

confidence: 99%

Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication

Rumyantceva

Andreeva

et al. 2021

IJMS

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“…A similar modelling can be done for more complex geometries, like vessel bifurcations and aneurism, which is an urgent medical problem for targeted drug delivery using controllable MNPs [18]. Different applications of magnetite nanoparticles in living systems for bioimaging, cancer and gene therapy, and blood coagulation [19], including designing of magnetically controlled systems for targeted delivery of thrombolytic drugs for cleavage of blood clots [20], would be benefi cial from presented modeling strategy.…”

Section: Discussionmentioning

confidence: 99%

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Salem¹,

Tuchin²

2020

ISUNSSP

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Magnetic nanoparticles, as controlled drug carriers, provide tremendous opportunities in treating a variety of tumors and brain diseases. In this theoretical study, we used magnetic nanoparticles, such as Superparamagnetic Iron Oxide Nanoparticles (Fe 3 O 4) (SPION). Due to their biocompatibility and stability, these particles represent a unique nanoplatform with a great potential for the development of drug delivery systems. This allows them to be used in medicine for targeted drug delivery, in magnetic resonance imaging and magnetic hyperthermia. In the work, the trapping mechanisms of magnetic nanoparticles moving in a viscous fluid (blood) in a static magnetic field are numerically studied. The equations of motion for particles in the flow are governed by a combination of magnetic equations for the permanent magnet field and the Navier-Stokes equations for fluid (blood). These equations were solved numerically using the COMSOL Multiphysics® Modeling Software.

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“…Currently, MONPs of almost 30 different chemical elements are described [5]. Among the most common are alumina [6,7], cerium [8], cobalt [9], copper [10], iron [11,12], gadolinium [13], hafnium [14], magnesium [15], manganese [16], silica, titanium [17], and zinc [18] MONPs.…”

Section: Metal Oxide Nanoparticles: a General Overviewmentioning

confidence: 99%

Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions

et al. 2019

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Macrophages are components of the innate immune system that control a plethora of biological processes. Macrophages can be activated towards pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes depending on the cue; however, polarization may be altered in bacterial and viral infections, cancer, or autoimmune diseases. Metal (zinc, iron, titanium, copper, etc.) oxide nanoparticles are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools. Macrophages can recognize and engulf nanoparticles, while the influence of macrophage-nanoparticle interaction on cell polarization remains unclear. In this review, we summarize the molecular mechanisms that drive macrophage activation phenotypes and functions upon interaction with nanoparticles in an inflammatory microenvironment. The manifold effects of metal oxide nanoparticles on macrophages depend on the type of metal and the route of synthesis. While largely considered as drug transporters, metal oxide nanoparticles nevertheless have an immunotherapeutic potential, as they can evoke pro- or anti-inflammatory effects on macrophages and become essential for macrophage profiling in cancer, wound healing, infections, and autoimmunity.

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Synthesis of Plasmin‐Loaded Fe₃O₄@CaCO₃ Nanoparticles: Towards Next‐Generation Thrombolytic Drugs

Cited by 12 publications

References 43 publications

Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication

Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions

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