Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Salem, Samia; Tuchin, Valery V.

doi:10.18500/1817-3020-2020-20-1-72-79

Cited by 3 publications

(2 citation statements)

References 17 publications

(25 reference statements)

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“…Using simulations in biomechanics and applications of biomedicine are very important study in the recent decades [1][2][3][4][5][6][7][8][9][10]. The results of this study can be used in many biomedical applications such as using magnetic nanoparticles in drug delivery and drug targeting as shown in my previous work [28].…”

Section: Discussionmentioning

confidence: 89%

Numerical Simulation of Blood Flow in a Vessel by Using COMSOL Multiphysics® Software

Salem

Tuchin

2020

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Dynamics of the blood flow play an important role in the development and treatment of cardiovascular diseases. In recent decades, blood flow simulation has been widely used to better understand the symptomatic spectrum of different diseases, in order to improve existing or develop new therapeutic techniques. Numerical simulation for biomagnetic fluid (such as blood) flow through a tube with rectangular cross section under the influence of magnetic field is studied in this work. Blood considered as a magnetic and incompressible fluid. The magnetic field effects on the blood stream in a tube are created by a permanent magnet outside the tube. The equations of motion which describe the flow is governed by the combination of magnetic equations for permanent magnet and Navier-Stokes equation for fluid (blood) were solved numerically by using COMSOL Multiphysics® Modeling Software.

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Section: Discussionmentioning

confidence: 89%

Numerical Simulation of Blood Flow in a Vessel by Using COMSOL Multiphysics® Software

Salem

Tuchin

2020

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“…At present, a number of articles considering the trapping of magnetically sensitive objects in flow have been published. The majority of these articles are dedicated to the study of magnetic nanoparticles' behavior in the bloodstream under the influence of a permanent magnetic field and modeling of their magnetic trapping [21][22][23][24][25]. A considerably smaller number of studies are devoted to the behavior of submicron-and micron-sized objects.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow

et al. 2022

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A promising approach to targeted drug delivery is the remote control of magnetically sensitive objects using an external magnetic field source. This method can assist in the accumulation of magnetic carriers in the affected area for local drug delivery, thus providing magnetic nanoparticles for MRI contrast and magnetic hyperthermia, as well as the magnetic separation of objects of interest from the bloodstream and liquid biopsy samples. The possibility of magnetic objects’ capture in the flow is determined by the ratio of the magnetic field strength and the force of viscous resistance. Thus, the capturing ability is limited by the objects’ magnetic properties, size, and flow rate. Despite the importance of a thorough investigation of this process to prove the concept of magnetically controlled drug delivery, it has not been sufficiently investigated. Here, we studied the efficiency of polyelectrolyte capsules’ capture by the external magnetic field source depending on their size, the magnetic nanoparticle payload, and the suspension’s flow rate. Additionally, we estimated the possibility of magnetically trapping cells containing magnetic capsules in flow and evaluated cells’ membrane integrity after that. These results are required to prove the possibility of the magnetically controlled delivery of the encapsulated medicine to the affected area with its subsequent retention, as well as the capability to capture magnetically labeled cells in flow.

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Numerical Studies on Magnetic Driven Targeted Drug Delivery in Human Vasculature

Tamboli,

Murallidharan

2024

J Indian Inst Sci

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Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Cited by 3 publications

References 17 publications

Numerical Simulation of Blood Flow in a Vessel by Using COMSOL Multiphysics® Software

Numerical Simulation of Blood Flow in a Vessel by Using COMSOL Multiphysics® Software

The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow

Numerical Studies on Magnetic Driven Targeted Drug Delivery in Human Vasculature

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