Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects

Khurana, Jitender M.; Magoo, Devanshi; Aggarwal, Komal; Aggarwal, Nisha; Kumar, Rajesh; Srivastava, Chitra

doi:10.1016/j.ejmech.2012.10.025

Cited by 47 publications

(25 citation statements)

References 18 publications

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“…The diverse applicability of xanthenes and xanthones in areas such as technology, photochemistry and biology [122] , [123] , [124] , [125] , [126] , [127] , [128] motivated the Khurana group to develop derivatives as potent urease inhibitors [129] . Based on the results of the urease inhibition assay, compounds with aryl groups carrying electron-donating groups at the para position exhibited the best inhibitory activity ( Scheme 44 ).…”

Section: Organic Substances As Urease Inhibitorsmentioning

confidence: 99%

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Rego

Queiroz

Brito

et al. 2018

Journal of Advanced Research

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Section: Organic Substances As Urease Inhibitorsmentioning

confidence: 99%

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Rego

Queiroz

Brito

et al. 2018

Journal of Advanced Research

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“…Xanthenes have been classified as oxygen-containing molecular families, found in natural products, synthetic bioactive substances, and fluorescent dyes. 1 The core structure of xanthene exhibits a variety of physicochemical and pharmacological properties such as antiviral, 2 antibacterial, 3 analgesic, 3 antimalarial, 4 antiinflammatory, 5 and anticancer. 6 Extensive literature survey has devoted for various routes for the synthesis of xanthenes, for example, sulfamic acid, 7 pTSA, 8 silica sulfuric acid, 9 molecular iodine, 10 TiO 2 –SO 4 2– , 11 NaHSO 4 –SiO 2 , 12 et cyanuric chloride, 13 amberlyst-15, 14 acyclic acidic ionic liquids, 15 core/shell Fe 3 O 4 @GA@isinglass, 16 and boric acid.…”

Section: Introductionmentioning

confidence: 99%

Fur-Imine-Functionalized Graphene Oxide-Immobilized Copper Oxide Nanoparticle Catalyst for the Synthesis of Xanthene Derivatives

et al. 2018

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Fur-imine-functionalized graphene oxide-immobilized copper oxide nanoparticles (Cu(II)-Fur-APTES/GO) are synthesized and found to be a cost-effective, efficient, and reusable heterogeneous nanocatalyst for the preparation of pharmaceutically important xanthene derivatives under greener solvent conditions. Cu(II)-Fur-APTES/GO exhibits excellent result in the synthesis of xanthenes with reduced reaction time (25−50 min) and higher yields (up to 95%) and has a simple procedure, ease of product separation, and no byproducts. Moreover, the nanocatalyst has a Cu loading of 13.5 at. % over functionalized GO which is far superior than the already known metal-based heterogeneous catalysts. The newly synthesized catalyst has been characterized by various physiochemical techniques such as X-ray photoelectron spectroscopy, X-ray diffraction, energy-dispersive X-ray, Raman spectroscopy for structural characterization, field emission scanning electron microscopy and high-resolution transmission electron microscopy for morphological characterization. The catalyst showed admirable recyclability up to five consecutive runs, and there was no appreciable loss in catalytic efficiency.

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“…Xanthenes are important heterocycles with a variety of applications in the field of pharmaceutical chemistry 1 . Notable pharmaceutical properties of xanthene derivatives are antibacterial 2 , analgesic, antiviral 3 , anti-inflammatory 4 , antimalarial 5 and anticancer 6 .…”

mentioning

confidence: 99%

Greener Route for Synthesis of aryl and alkyl-14H-dibenzo [a.j] xanthenes using Graphene Oxide-Copper Ferrite Nanocomposite as a Recyclable Heterogeneous Catalyst

Kumar

Rout

Achary

et al. 2017

Sci Rep

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A facile, efficient and environmentally-friendly protocol for the synthesis of xanthenes by graphene oxide based nanocomposite (GO-CuFe2O4) has been developed by one-pot condensation route. The nanocomposite was designed by decorating copper ferrite nanoparticles on graphene oxide (GO) surface via a solution combustion route without the use of template. The as-synthesized GO-CuFe2O4 composite was comprehensively characterized by XRD, FTIR, Raman, SEM, EDX, HRTEM with EDS mapping, XPS, N2 adsorption-desorption and ICP-OES techniques. This nanocomposite was then used in an operationally simple, cost effective, efficient and environmentally benign synthesis of 14H-dibenzo xanthene under solvent free condition. The present approach offers several advantages such as short reaction times, high yields, easy purification, a cleaner reaction, ease of recovery and reusability of the catalyst by a magnetic field. Based upon various controlled reaction results, a possible mechanism for xanthene synthesis over GO-CuFe2O4 catalyst was proposed. The superior catalytic activity of the GO-CuFe2O4 nanocomposite can be attributed to the synergistic interaction between GO and CuFe2O4 nanoparticles, high surface area and presence of small sized CuFe2O4 NPs. This versatile GO-CuFe2O4 nanocomposite synthesized via combustion method holds great promise for applications in wide range of industrially important catalytic reactions.

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Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects

Cited by 47 publications

References 18 publications

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Fur-Imine-Functionalized Graphene Oxide-Immobilized Copper Oxide Nanoparticle Catalyst for the Synthesis of Xanthene Derivatives

Greener Route for Synthesis of aryl and alkyl-14H-dibenzo [a.j] xanthenes using Graphene Oxide-Copper Ferrite Nanocomposite as a Recyclable Heterogeneous Catalyst

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