Synthesis of nanohydrogels based on tragacanth gum biopolymer and investigation of swelling and drug delivery

Hosseini, Masoomeh Sadat; Hemmati, Khadijeh; Ghaemy, Mousa

doi:10.1016/j.ijbiomac.2015.09.067

Cited by 94 publications

(30 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The band at 1,420 cm −1 was assigned to the C-OH deformation vibration with the contribution of C-O-C symmetric stretching vibration of the carboxylate group. The band at ~1,160 cm −1 was associated with C-O-C asymmetric stretching vibration in the glycosidic groups of polysaccharides (13). The absorption peak at 914 cm −1 was caused by D-glucopyranose, and the presence of a β-glycosidic bond was indicated by the band at ~760 cm −1 (14).…”

Section: Resultsmentioning

confidence: 99%

Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism

Zhao¹,

Zhang²,

Han³

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

In the present study, a novel polysaccharide, APS2-1, was isolated and purified from Astragalus membranaceus using DEAE-cellulose and Sephadex G-100 chromatography. The effect of APS2-1 on the promotion of wound healing was evaluated and its preliminary mechanism was investigated. In vitro experiments showed that APS2-1 was able to promote human skin fibroblast (HSF) propagation and accelerate cell cycle progression. For further examination, a scalded mice model was used to verify the effect of APS2-1 and investigate its mechanism of action. The analysis of biochemical parameters, including cyclin D1, inhibitor of nuclear factor κBα (IκBα), transforming growth factor (TGF)-β1, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) showed that APS2-1 inhibited the increase in cyclin D1 and IκBα, and promoted the expression of TGF-β1, bFGF and EGF, which was further confirmed by histopathological observation. These results suggested that APS2-1 possessed high potential in wound healing and its mechanism was associated with inhibiting inflammation, accelerating cell cycle and promoting the secretion of repair factors.

show abstract

Section: Resultsmentioning

confidence: 99%

Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism

Zhao¹,

Zhang²,

Han³

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…Samples were taken out after the required time, wiped with a tissue and weighed. The swelling was calculated as per the following equation:

Swelling (%) = \frac{W_{normals} - W_{0}}{W_{0}} \times 100

…”

Section: Methodsmentioning

confidence: 99%

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma

Negi

Pathania

et al. 2018

Polymer International

View full text Add to dashboard Cite

Graft polymerization of itaconic acid on tragacanth gum (TG) was carried out using potassium persulfate as initiator to develop smart hydrogels for drug delivery systems. The effect of the grafting parameters on the degree of grafting was investigated. The grafting was significantly influenced by the reaction medium, the reaction temperature and the monomer concentration. The monomer dependency of the system was found to be 1.52. The hydrogels were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry and X‐ray diffraction. The grafted TG had an amorphous nature and exhibited excellent swelling in water and strong dependence on the pH of the medium. The grafted TG showed pH‐dependent release of ciprofloxacin which offers the possibility of using these materials in colon‐specific drug targeting for human healthcare systems. © 2018 Society of Chemical Industry

show abstract

“…Antibacterial Cefixime CS/PEG Atta et al [43] Antibacterial and anticancer Polymyxin and paclitaxel Methacrylated mucin Duffy et al [44] Anti-inflammatory Indomethacin TGAP and TGAP-GDE Hosaini et al [45] Antibacterial Escherichia coli and staphylococcus aureus CS-ZnO NPs Yadollahi et al [46] Antibacterial Escherichia coli and staphylococcus aureus CS-Ag NPs Yadollahi et al [47] Anti-inflammatory Diclofenac sodium CMC-AgNPs Gulsonbi et al [48] Respiratory activity Theophylliine CNC-Gt Ooi et al [49] Anti-inflammatory Indomethacin PLGA-NH 2 -Gt Chung et al [50] Anti-inflammatory and anticancer 5-Fluorouracil and diclofenac CMCS-PNIPA m -GMA Zhang et al [51] Anti-inflammatory Aspirin CD-g-CMCs Kono et al [52] tissue. These hydrogels are retained and released linearly both paclitaxel and polymyxin B drugs with time over seven days.…”

Section: Biomedical Application Model Drug Used Types Of Hydrogels Rementioning

confidence: 99%

“…Hosaini et al [49] were prepared pH responsive nanohydrogels with biopolymer tragacanth gum for drug delivery system using 3-aminopropyltriethoxysilane as a modifier and glycerol diglycidyl ether, polyvinyl alcohol and glutaraldehyde as a cross linker. The nanogel contents were increased with respect to increase of cross linker and reached at a maximum of 90% due to the formation of an interpenetrating network with chemical cross linking between tragacanth gum and cross linkers.…”

Section: Biomedical Application Model Drug Used Types Of Hydrogels Rementioning

confidence: 99%

Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

Gopi¹,

Amalraj²,

Thomas³

2016

Drug Des

View full text Add to dashboard Cite

Design and synthesis of well-ordered drug delivery systems are very important for medicinal and pharmaceutical and health care. Innovations of materials through nanotechnology and hydrogels have synergistically energized the growth of drug delivery. Uniqueness in material chemistry permits the creation of environmentally approachable, biocompatible, biodegradable and targeted drug delivery system. Large numbers of biopolymers have been examined for the design of drug delivery systems. Structure, size, shape and multi-functionality of drug delivery system can be controlled by the nanotechnology combined with biopolymer. Hydrogels have also been investigated as smart delivery systems capable to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. This review mainly focuses on drug delivery applications of nanoparticles modified biopolymers and effective drug delivery system of biopolymer network based on hydrogels.

show abstract

Synthesis of nanohydrogels based on tragacanth gum biopolymer and investigation of swelling and drug delivery

Cited by 94 publications

References 22 publications

Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism

Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

Contact Info

Product

Resources

About