Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

Gopi, Sreeraj; Amalraj, Augustine; Thomas, Sabu

doi:10.4172/2169-0138.1000129

Cited by 57 publications

(40 citation statements)

References 42 publications

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“…Nano‐formulation methods have become most promising applications compared to traditional ones, to increase skin penetration and reduce the toxicity of topical drugs . In recent years, drug industry has focused on the utilization of biodegradable polymeric nanoparticles as effective drug delivery agents . There are many synthetic polymers used for nano‐formulations .…”

Section: Introductionmentioning

confidence: 99%

Piperine Nanoparticles for Topical Application: Preparation, Characterization,In vitroandIn silicoEvaluation

Budama‐Kilinc

2019

ChemistrySelect

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In this study, piperine was investigated as a drug molecule due to its analgesic and anti‐inflammatory properties. Piperine was encapsulated with poly(lactic‐co‐glycolic acid) (PLGA) in order to increase drug bioavailability for topical applications. Characterization of piperine PLGA nanoparticles (NPs) were performed with spectroscopic and imaging methods. It was found that the piperine PLGA NPs were successfully prepared according to the analyses. The encapsulation efficiency and loading capacity of the piperine were calculated as 99% and 3%, respectively. In vitro release study was also performed. Besides, it was shown that piperine had no mutagenic effect. Finally, molecular docking simulation was performed by using the AutoDock Vina program to identify the interaction between piperine and COX‐1 and COX‐2 enzymes. The aim of this study is to contribute to the design of plant derived nano‐formulations for local anti‐inflammation and pain treatment with better skin penetration.

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Section: Introductionmentioning

confidence: 99%

Piperine Nanoparticles for Topical Application: Preparation, Characterization,In vitroandIn silicoEvaluation

Budama‐Kilinc

2019

ChemistrySelect

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“…Swelling behavior is a key aspect for the NPs that behave as carriers of drugs or different bioactive agents for sustained release (Gopi et al, 2016). There are several ways in which drugs that are in NPs are released (Prasad et al, 2016).…”

Section: Swelling Degree and Dissolution Ratementioning

confidence: 99%

Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery

et al. 2020

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2020) Preparation and characterization of novel anti-inflammatory biological agents based on piroxicamloaded poly-ε-caprolactone nano-particles for sustained NSAID delivery, Drug Delivery, 27:1, 269-282, ABSTRACT Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-e-caprolactone (PCL) nanoparticles (NPs) offer potential advantages over conventional oral delivery. The purpose of this study is the development of a new type of anti-inflammatory bio-agents containing collagen and PX-loaded NPs, as an example for an oral formulation replacement, for the prolonged release of PX. In this study, the PX was encapsulated in PCL NPs (size 102.7 ± 19.37 nm, encapsulation efficiency 92.83 ± 0.4410) by oil-in-water (o/w) emulsion solvent evaporation method. Nanoparticles were then characterized for entrapment efficiency, percent yield, particle size analysis, morphological characteristics, and in vitro drug release profiles. Eventually, the NPs synthesized with collagen were conjugated so that the NPs were trapped in the collagen sponges using a cross-linker. Finally, biocompatibility tests showed that the anti-inflammatory agents made in this study had no toxic effect on the cells. Based on the results, it appears that PX-loaded PCL NPs along with collagen (PPCLnp-Coll) can be promising for IA administration based on particulate drug delivery for the treatment of arthritis. ARTICLE HISTORY

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“…Synthetic polymers [13], polymers from the biological sources [14], and proteins that are biodegradable, biocompatible, and have low toxicity [15], can be used as matrixes for the composite microparticles.…”

Section: Introductionmentioning

confidence: 99%

Formation of microspherical particles of albumin with model drug using spray drying process

2019

Biointerface Res Appl Chem

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Spray drying method enables to produce microspherical particles with narrow size distribution. Production of such microparticles is relevant for the development of the advanced systems for inhalation delivery of drugs. The aerosol particles diameter must be between 1 and 3 μm. Composite microparticles based on bovine serum albumin and model drug phenacetin were produced in the present work using the spray-drying method. The absence of a crystalline phase of the drug in composite microparticles was verified using several physicochemical methods. The average radius of the produced microparticles was found to be 1 μm based on the results from scanning electron microscopy. The rate of the dissolution of the drug included in microparticles is faster than that of crystalline phenacetin. The obtained results can be used for the development of the method for preparation of composite microparticles based on protein molecules using the spray-drying technique.

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Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review

Cited by 57 publications

References 42 publications

Piperine Nanoparticles for Topical Application: Preparation, Characterization,In vitroandIn silicoEvaluation

Piperine Nanoparticles for Topical Application: Preparation, Characterization,In vitroandIn silicoEvaluation

Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery

Formation of microspherical particles of albumin with model drug using spray drying process

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