Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery

Bakhshayesh, Azizeh Rahmani Del; Akbarzadeh, Abolfazl; Alihemmati, Alireza; Nasrabadi, Hamid Tayefi; Montaseri, Azadeh; Davaran, Soodabeh; Abedelahi, Ali

doi:10.1080/10717544.2020.1716881

Cited by 23 publications

(9 citation statements)

References 50 publications

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“…[33] Nanotechnology-based drug delivery systems have been explored for improving the pharmacodynamics and pharmacokinetics of osteoarthritis drugs through targeted and sustained therapeutic action with fewer systemic adverse effects and longer-term benefits. [34][35][36][37][38] Maudens et al [39] developed kartogenin nanocrystal-polymer particles for effective treatment of osteoarthritis with a very high drug loading over an extended period of time as a controlled drug release system. Kartogenin is a small heterocyclic molecule with the ability of cartilage protection and regeneration.…”

Section: Osteoarthritismentioning

confidence: 99%

Nanotechnology-based drug delivery systems in orthopedics

Güven

2021

Jt Dis Relat Surg

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Nanotechnology is a multidisciplinary branch of science which involves the manipulation and control of matter at the nanometer scale to produce new structures, materials, and devices. The concept of nanotechnology was first introduced by Richard P. Feynman [1] in 1959. Since then, nanotechnology has become a research area which promises advancements in many aspects of human life, including electronics, agriculture, transportation, food industry, communication, energy, biological sciences, and medicine. Nanomedicine, the application of nanotechnology in the field of medicine, has the potential to make a great impact on human health and has already impacted and reshaped many aspects of clinical practice and research. Nanotechnology-based materials with unique physical, chemical, and biological characteristics offer a variety of new approaches for clinical practices ranging from prevention to treatment and diagnosis of many diseases and conditions. [2][3][4][5] Among all the applications of nanotechnology in medicine, nano-based drugIn recent years, nanotechnology has led to significant scientific and technological advances in diverse fields, specifically within the field of medicine. Owing to the revolutionary implications in drug delivery, nanotechnology-based drug delivery systems have gained an increasing research interest in the current medical field. A variety of nanomaterials with unique physical, chemical and biological properties have been engineered to develop new drug delivery systems for the local, sustained and targeted delivery of drugs with improved therapeutic efficiency and less or no toxicity, representing a very promising approach for the effective management of diseases. The utility of nanotechnology, particularly in the field of orthopedics, is a topic of extensive research. Nanotechnology has a great potential to revolutionize treatment, diagnostics, and research in the field of orthopedics. Nanophase drug delivery has shown great promise in their ability to deliver drugs at nanoscale for a variety of orthopedic applications. In this review, we discuss recent advances in the field of nanostructured drug delivery systems for orthopedic applications.

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Section: Osteoarthritismentioning

confidence: 99%

Nanotechnology-based drug delivery systems in orthopedics

Güven

2021

Jt Dis Relat Surg

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“…Some researchers have used solid scaffolds for cartilage tissue engineering for large defects [158]. Among the solid scaffolds, collagen sponge was widely used to the cartilage engineering [159,160] (Figure 3).…”

Section: Biomaterials Engineering For Construction Of Scaffoldsmentioning

confidence: 99%

An overview of various treatment strategies, especially tissue engineering for damaged articular cartilage

Bakhshayesh

Babaie

Nasrabadi

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Many traditional procedures, including surgical methods such as microfracture of subchondral bone and soft tissue transplantation, have been widely used to treat damaged cartilage. However, there is still no definitive cure for cartilage defects. In recent decades, tissue engineering has raised hopes for the repair of defective cartilage. Different approaches are used for cartilage engineering, in which cells, scaffolds, and biological signals or growth factors may be used alone or in combination. Additionally, the imitation of the mechanical properties of the natural cartilage tissue by bioreactors is also helpful in this regard. It should be noted that in the transplantation of engineered cartilage tissue, there are challenges such as poor integration, inflammation and phenotypic instability that may lead to failure of neo-cartilage transplantation. Therefore, a comprehensive understanding of the multiple therapeutic approaches, including surgical procedures, cell-based methods and tissue engineering, should be obtained. The present review article provides this information, along with a variety of factors, including cells, materials, and biological/biomechanical factors required for the engineering of cartilage tissue, as well as the challenges ahead and their solutions.

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“…Drug delivery carriers for targeted delivery in osteoarthritis can be fabricated by taking the advantage of anatomical physiology of inflamed area (passive targeting) or utilizing homing devices or ligands to specifically bind with target site receptors (active targeting). 3,4 Novel route of drug administration with sustain and targeted delivery aid in reducing systemic toxicities. Transdermal drug delivery system (TDDS) aimed to deliver drug through the skin into systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

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A u t h o r`s C o n t r i b u t i o n1 Literature search and analysis on nanocarriers, writing 2 Literature survey for chitosan 3 Literature survey of inflammatory pathway A r t i c l e I n f o .

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mentioning

confidence: 99%

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Gul

Jahan

Naseer

2021

JSTMU

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Osteoarthritis is characterized by joint destruction followed by severe inflammation caused by variety of proinflammatory mediators released due to upregulation of nuclear translocation of nuclear factor (NF-kB). Current treatment involves chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs) that is associated with bewildering array of systemic adverse effects. Transdermal drug delivery system address challenges of systemic toxicities but toxic chemical penetration enhancers limit its utility. Novel drug delivery system explores the potential of bio-inspired materials for designing of safe and effective carriers that specifically deliver drug to site of action with enhanced transdermal penetration of the drug. Chondroitin sulfate, a biopolymer that mimic extracellular matrix, binds specifically with its overexpressed receptors (CD44, RHAMM and ICAM-I) at inflammatory site, biodegradable and possess intrinsic anti-inflammatory properties. These attributes render chondroitin sulfate an ideal carrier for the drug delivery in osteoarthritis. Chondroitin sulfate based nanocarriers serve as a potential drug delivery system that not only deliver anti-arthritis drug through the skin but also produce synergistic effect to improve therapeutic outcome. In this review, molecular mechanism of intrinsic anti-inflammatory effects of chondroitin sulfate in osteoarthritis is discussed in detail. Moreover, potential of chondroitin sulfate to perform dual role of therapeutic agent as well as serve as nanocarrier in transdermal drug delivery for the treatment of osteoarthritis is elaborated.

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Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery

Cited by 23 publications

References 50 publications

Nanotechnology-based drug delivery systems in orthopedics

Nanotechnology-based drug delivery systems in orthopedics

An overview of various treatment strategies, especially tissue engineering for damaged articular cartilage

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

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