Synthesis of MoSe₂/CoSe₂ Nanosheets for NIR‐Enhanced Chemodynamic Therapy via Synergistic In‐Situ H₂O₂ Production and Activation

Abstract

Currently, the limited intratumoral H2O2 level restricts the development of chemodynamic therapy (CDT). Herein, MoSe2/CoSe2@PEG nanosheets are prepared to reveal NIR‐photocatalytic H2O2 generation to insure the intracellular H2O2 supplement. The formation mechanism is investigated, showing the dissolved O2 and photo‐excited electrons to determine H2O2 production via sequential single‐electron transfer process. The experimental data and density functional theory calculation further display their typical‐II heterostructure, which possesses the effective charge separation and nearly four times H2O2 generation than MoSe2@PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in‐situ H2O2 activation and ·OH generation. And, the O2 production derived from catalase‐mimic activity not only relieves hypoxia but also offers the source for H2O2 production. Because of the decreased resistance for charge transfer, MoSe2/CoSe2@PEGs also reveal more than three times enzyme‐activity for MoSe2@PEG. With the narrow band gap and high NIR‐harvest, MoSe2/CoSe2@PEG exhibits the great photothermal converting ability (62.5%). MoSe2/CoSe2@PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.

Chemodynamic nanomaterials for cancer theranostics

“…Besides iron, manganese and copper, Fenton-like reactions can be catalyzed by other metal cations, such as Ti 3+ , Ir 3+ , Cr 4+ , Ce 3+ , Co 3+ , and Mo 3+ [ 108 – 111 ]. For example, a ruthenium complex (abbreviated as N3) was conjugated to a TiO 2 NP to produce TiO 2 -N3 [ 67 ].…”

“…When exposing TiO 2 -N3 to light, it produced three- and four- fold more cytotoxic •OH than TiO 2 intrinsically. In another example, using prepared MoSe 2 /CoSe 2 @PEG NPs, near infrared (NIR) light not only triggered PTT but also induced the efficient electron–hole separation to result in efficient H 2 O 2 generation [ 111 ]. The generated H 2 O 2 was further decomposed into •OH via the Fenton-like reaction.…”

Oxidative burst as a continuous H2O2 supplier for tumor oxygenation in photodynamic therapy

“…17 Thus, it is urgent to find an effective strategy to enhance endogenous H 2 O 2 concentration. 21 Thus, co-delivery of these candidates with PS to cancer cells can effectively relieve tumor hypoxia to enhance the PDT outcome.…”

NIR‐Triggered Multi‐Mode Antitumor Therapy Based on Bi2Se3/Au Heterostructure with Enhanced Efficacy

“…[22] Therefore, for promoting the electron-hole separation, construction of heterostructured semiconductor nanomaterials has been intensively developed as an effective strategy. [23] To date, semiconductor/semiconductor [24][25][26] and inorganic nonmetal/semiconductor [12,27,28] heterostructured photocatalysts have been fabricated to improve the photocatalytic efficiency. For instance, MoSe 2 /CoSe 2 heterostructured nanosheets [26] and Ti 3 C 2 /g-C 3 N 4 two-dimensional heterostructures [27] both contribute to the NIR-triggered ROS generation.…”

“…[23] To date, semiconductor/semiconductor [24][25][26] and inorganic nonmetal/semiconductor [12,27,28] heterostructured photocatalysts have been fabricated to improve the photocatalytic efficiency. For instance, MoSe 2 /CoSe 2 heterostructured nanosheets [26] and Ti 3 C 2 /g-C 3 N 4 two-dimensional heterostructures [27] both contribute to the NIR-triggered ROS generation. Nevertheless, the specific position of conduction band (CB) and valence band (VB) limited by complicated Z-scheme mechanism remains a great challenge for the design of heterostructures, [29] which would hinder the PCT application.…”