Soft ionic conductors, such as hydrogels and ionogels, have enabled stretchable and transparent ionotronics, but they suffer from key limitations inherent to the liquid components, which may leak and evaporate. Here, novel liquid‐free ionic conductive elastomers (ICE) that are copolymer networks hosting lithium cations and associated anions via lithium bonds and hydrogen bonds are demonstrated, such that they are intrinsically immune from leakage and evaporation. The ICEs show extraordinary mechanical versatility including excellent stretchability, high strength and toughness, self‐healing, quick self‐recovery, and 3D‐printability. More intriguingly, the ICEs can defeat the conflict of strength versus toughness—a compromise well recognized in mechanics and material science—and simultaneously overcome the conflict between ionic conductivity and mechanical properties, which is common for ionogels. Several liquid‐free ionotronics based on the ICE are further developed, including resistive force sensors, multifunctional ionic skins, and triboelectric nanogenerators (TENGs), which are not subject to limitations of previous gel‐based devices, such as leakage, evaporation, and weak hydrogel–elastomer interfaces. Also, the 3D printability of the ICEs is demonstrated by printing a series of structures with fine features. The findings offer promise for a variety of ionotronics requiring environmental stability and durability.

Carrier doping of MoS2 nanoflakes was achieved by functional self-assembled monolayers (SAMs) with different dipole moments. The effect of SAMs on the charge transfer between the substrates and MoS2 nanoflakes was studied by Raman spectroscopy, field-effect transistor (FET) measurements, and Kelvin probe microscope (KFM). Raman data and FET results verified that fluoroalkyltrichlorosilane-SAM with a large positive dipole moment, acting as hole donors, significantly reduced the intrinsic n-doping characteristic of MoS2 nanoflakes, while 3-(trimethoxysilyl)-1-propanamine-SAMs, acting as electron donors, enhanced the n-doping characteristic. The additional built-in electric field at the interface between SiO2 substrates and MoS2 nanoflakes induced by SAMs with molecular dipole moments determined the charge transfer process. KFM results clearly demonstrated the charge transfer between MoS2 and SAMs and the obvious interlayer screening effect of the pristine and SAM-modified MoS2 nanoflakes. However, the KFM results were not fully consistent with the Raman and FET results since the externally absorbed water molecules were shown to partially shield the actual surface potential measurement. By eliminating the contribution of the water molecules, the Fermi level of monolayer MoS2 could be estimated to modulate in a range of more than 0.45-0.47 eV. This work manifests that the work function of MoS2 nanoflakes can be significantly tuned by SAMs by virtue of affecting the electrostatic potential between the substrates and MoS2 nanoflakes.

Fibroblast growth factor 21 (FGF21) is a distinctive member of the FGF family with potent beneficial effects on lipid, body weight, and glucose metabolism and has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to native FGF21, we have developed a monoclonal antibody, mimAb1, that binds to βKlotho with high affinity and specifically activates signaling from the βKlotho/FGFR1c (FGF receptor 1c) receptor complex. In obese cynomolgus monkeys, injection of mimAb1 led to FGF21-like metabolic effects, including decreases in body weight, plasma insulin, triglycerides, and glucose during tolerance testing. Mice with adipose-selective FGFR1 knockout were refractory to FGF21-induced improvements in glucose metabolism and body weight. These results in obese monkeys (with mimAb1) and in FGFR1 knockout mice (with FGF21) demonstrated the essential role of FGFR1c in FGF21 function and suggest fat as a critical target tissue for the cytokine and antibody. Because mimAb1 depends on βKlotho to activate FGFR1c, it is not expected to induce side effects caused by activating FGFR1c alone. The unexpected finding of an antibody that can activate FGF21-like signaling through cell surface receptors provided preclinical validation for an innovative therapeutic approach to diabetes and obesity.

We report a newly developed self-contained interface for high-vapor pressure liquid surfaces to vacuum-based analytical instruments. It requires no wires or tubing connections to the outside of the instrument and uses a microfluidic channel with a 3 μm diameter window into the flowing fluid beneath it. This window supports the liquid against the vacuum by the liquid's surface tension and limits the high-density vapor region traversed by the probe beams to only a few microns. We demonstrate this microfluidic interface for in situ liquid surfaces in a time-of-flight secondary ion mass spectrometer (ToF-SIMS) and a scanning electron microscope (SEM) with chemical analysis.