Synthesis, Characterization and in Vitro Biological Studies of Novel Schiff Base and Its Transition Metal Complexes Derived From Sulphadoxine

Mumtaz, Amina

doi:10.31925/farmacia.2019.1.14

Cited by 6 publications

(2 citation statements)

References 20 publications

(24 reference statements)

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“…The bactericidal properties of DEP and [DEP(M)X 2 ] complexes were assessed using agar standard diffusion procedure against S. typhi, S. aureus, E. coli, and P. aeruginosa bacterial strains by media preparation methods. 35,36 These bacterial strains were tested against three different concentrations, that is, 500, 250, and 100 μg ml À1 of assessed compounds (dissolved in DMSO) using Chloramphenicol as a standard drug with the same concentrations. The inhibition zone formed around the well (in mm) was used for measuring antimicrobial activity.…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

Nayab

Faisal

Khan

et al. 2023

Applied Organom Chemis

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Herein, Cu (II), Zn (II), and Cd (II) complexes, [DEP(M)X2], encompassing the pyridine‐derived Schiff‐base ligand DEP, where DEP is (E)‐N,N‐diethyl‐2‐([pyridine‐2‐ylmethylene]amino)ethane‐1‐amine, are synthesized. X‐ray diffraction studies reveal distorted square pyramidal geometries for the Cd (II) and Cu (II) complexes, whereas the geometry of [DEP (Zn)Cl2] can best be described as trigonal bipyramidal. The antibacterial potential of DEP and its [DEP(M)X2] complexes were evaluated against four bacterial strains: Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa; five fungal strains: Candida glabrata, Candida albicans, Microsporum canis, Fusarium solani, and Aspergillus flavus; and Leishmania major protozoan. Complexes exhibited superior bactericidal, fungicidal, and leishmanicidal inhibition potential against all tested microbes compared with the free ligand. The preliminary cytotoxic activity of [DEP(M)X2] complexes on breast and colon carcinoma cells, that is, MCF‐7cell line and HCT‐116 cell line, respectively, revealed that studied complexes showed high cytotoxicity compared with ligand (DEP). Among the studied complexes, [DEP (Cd)Br2] exhibited an excellent inhibitory profile, as confirmed by the docking study. The molecular docking studies showed a good correlation between the biological activities of synthesized metal complexes and docking studies. We have confidence in the contribution of these complexes toward the design of new metal‐derived candidates that can treat infectious diseases.

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Section: Antibacterial Studiesmentioning

confidence: 99%

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

Nayab

Faisal

Khan

et al. 2023

Applied Organom Chemis

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“…Due to their characteristic properties, such as structural variety, thermal stability and coordination capacity, these compounds have potential applications in different fields [28]. Schiff bases present various biological activities such as antimicrobial [8,16,18], antitubercular [23], antihelmintic [12], anticancer [25], antioxidant [21], analgesic [9], anti-inflammatory [17], anticonvulsant [20], antidiabetic [26], antidepressant [30]. These compounds are also used as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers and corrosion inhibitors [2,4,7,11].…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Synthesis and Spectroscopic Characterization of Some Novel Schiff Bases of Carprofen Hydrazide

Bordei¹

2019

FARMACIA

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A new series of Schiff bases was synthesised by the treatment of (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide (carprofen hydrazide) with few benzaldehyde derivatives under microwave irradiation. The IR, 1 H NMR and 13 C NMR spectroscopic characterization of newly synthesised compounds is reported. The Schiff bases were tested for antibacterial activity, the strongest effect being against S. aureus. RezumatA fost sintetizată o serie nouă de baze Schiff, prin tratarea (2RS)-2-(6-cloro-9H-carbazol-2-il)propanohidrazidei (hidrazida carprofenului) cu derivați ai benzaldehidei, prin iradiere cu microunde. Este raportată caracterizarea spectrală IR, 1 H RMN și 13 C RMN a compușilor nou sintetizați. Bazele Schiff au fost testate din punct de vedere al activității antibacteriene efectul cel mai pronunțat înregistrându-se împotriva S. aureus.

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Structural investigation, molecular docking, X‐ray studies, and in vitro biological activities of new transition metal complexes based isoleucine‐pyridyl hybrid Schiff base

Saleh,

Alsubaie,

Moustafa

et al. 2024

Applied Organom Chemis

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One significant class of chemotherapeutic medicines with the ability to overcome drug resistance is metal‐based medications. The creation of novel therapeutic medications with distinct modes of action is required due to the rise in drug resistance, treatment failures, and the scarcity of available treatments. The amino acid isoleucine interacts with the arylidene (synthesized from isatin and 2,6‐diamino‐pyridine) forming the HL Schiff base ligand, which then interacts with some transition metal ions to form the metal complexes. Thermal analysis, spectroscopy (1H‐NMR, IR, mass, and ultraviolet–visible), solid reflectance, magnetic moment, molar conductivity, and elemental analyses were employed for examining the synthesized HL and resultant complexes. Mass spectra besides elemental analyses studies verified the formulae of the Schiff base ligand and metal complexes. All the complexes, except for the Fe(III) complex which is non‐electrolyte, exhibited electrolytic behavior as indicated by their molar conductivity values. The obtained complexes exhibited octahedral geometrical shapes, except for the complexes of Co(II), Ni(II), and Zn(II), which displayed tetrahedral geometry. Thermal analysis showed that the complexes consistently release organic ligands and anionic components following the initial loss of water molecules of hydration. The conducted X‐ray diffraction patterns elucidated their lattice dynamics and not only confirmed the purity of the samples, but also demonstrated that the ligand and complexes of Cr(III), Fe(III), Mn(II), Cu(II), Zn(II), and Cd(II) have a crystalline structure in addition to determination of average size of the crystallites. Scanning electron microscope (SEM) was investigated for Schiff base ligand and Co(II) complex. The complexes demonstrated superior efficacy than HL towards fungal and bacteria organisms against Aspergillus fumigatus and Candida albicans, Salmonella Sp., Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. The MCF‐7 cancer cell was subjected to investigation by synthesized complexes and IC50 values ranged from 12 to 23.1 μg/ml. Molecular docking studies define and anticipate the inhibitory potential and binding mode of the generated ligand with the 1GS4, 2HQ6, 3DJD, and 5JPE receptors.

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Synthesis, Characterization and in Vitro Biological Studies of Novel Schiff Base and Its Transition Metal Complexes Derived From Sulphadoxine

Cited by 6 publications

References 20 publications

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

Microwave Assisted Synthesis and Spectroscopic Characterization of Some Novel Schiff Bases of Carprofen Hydrazide

Structural investigation, molecular docking, X‐ray studies, and in vitro biological activities of new transition metal complexes based isoleucine‐pyridyl hybrid Schiff base

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