New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.
Two step synthesis of Schiff base ligand and its transition metal complexes was done by condensation reaction. In first step, the drug and aldehyde in equimolar ratio were refluxed for one hour at pH 8-9 in order to get Schiff base ligand. In second step, ligand and metal salts were refluxed for 2 hour. The ligand and Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) complexes were characterized by using different instruments like FT-IR, 1H-NMR, 13C-NMR, Mass, Atomic absorption spectrometer, Elemental analyzer, UV-visible spectrophotometer, Evans balance, Conductivitymeter and Thermogravimeter. In vitro antibacterial, antifungal and anti-inflammatory activities were also studied. The synthesized ligand and transition metal complexes were tested against Escherichia coli, Enterobacter aerogenes, Staphylococcus aureus, Bacillus pumilus, Klebsiella oxytoca, Clostridium butyrium, Mucor and Aspergillus niger. These studies demonstrated the enhanced activity of metal complexes against reported bacterial and fungal strains when compared with free Schiff base ligand. The Cu(II) complex recognized as anti-inflammatory agent while the parent drug showed no activity.
The new series of coordination transition metal complexes were preparedfrom Schiff base obtained from sulphadoxineandthiophene-2-carboxaldehyde. The structural investigation of Schiff base and their complexes were characterized by different instrumental procedures like microanalysis, spectroscopic andthermogravimetric examination. The integrated Schiff base ligand and transition metal complexes were subjected to antibacterial and antifungal activities.The studies demonstrated the enhanced activity of metal complexes against reported microbeswhen compared with free ligand.
RezumatO nouă serie de combinații complexe ale unor metale tranziționale a fost sintetizată pornind de la baza Schiff obținută din sulfadoxină și tiofen-2-carboxaldehidă. Structurile bazei Schiff și a complecșilor au fost caracterizate prin diferite procedee instrumentale cum ar fi microanaliza, spectroscopia și termogravimetria și au fost investigate activitățile lor antibacteriene și antifungice. Studiile au demonstrat o activitate antimicrobiană superioară a complexelor metalice în comparație cu ligandul liber.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.