A new series of Schiff bases was synthesised by the treatment of (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide (carprofen hydrazide) with few benzaldehyde derivatives under microwave irradiation. The IR, 1 H NMR and 13 C NMR spectroscopic characterization of newly synthesised compounds is reported. The Schiff bases were tested for antibacterial activity, the strongest effect being against S. aureus.
RezumatA fost sintetizată o serie nouă de baze Schiff, prin tratarea (2RS)-2-(6-cloro-9H-carbazol-2-il)propanohidrazidei (hidrazida carprofenului) cu derivați ai benzaldehidei, prin iradiere cu microunde. Este raportată caracterizarea spectrală IR, 1 H RMN și 13 C RMN a compușilor nou sintetizați. Bazele Schiff au fost testate din punct de vedere al activității antibacteriene efectul cel mai pronunțat înregistrându-se împotriva S. aureus.
(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (EZ)-N′-benzylidene-(2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound 1e had a high potential to be used as a good candidate in neurodegenerative disorders treatment.
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