Synthesis and characterization of curcumin loaded PLA—Hyperbranched polyglycerol electrospun blend for wound dressing applications

Perumal, Govindaraj; Pappuru, Sreenath; Chakraborty, Debashis; Nandkumar, A. Maya; Chand, Dillip Kumar; Doble, Mukesh

doi:10.1016/j.msec.2017.03.200

Cited by 154 publications

(102 citation statements)

References 44 publications

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“…For instance, PLAs are applied in orthopedics from tissue engineering scaffolds to internal fixation implants, a study provided an alternative for the used PLA implants currently, and explicated the positive effects of Mg/PLA composites on the osteogenesis and degradation . The curcumin incorporated electrospun nanofibers/hyperbranched polyglycerol/PLA blend could be used for wound healing, the result indicates that the migration of the cells in the scratch treated with Cur/HPG/PLA composites is completed within 36 h, PLA can be applied as novel patches for healing acute/chronic diabetic wound . Because of its excellent properties such as high mechanical properties and outstanding processing performance, PLAs are used in three‐dimensional (3D) print and other manufacturing field, PLA 3D print has attracted increasingly interest from other scholars …”

Section: Introductionmentioning

confidence: 99%

Effect of polyethylene glycol on mechanical properties of bamboo fiber‐reinforced polylactic acid composites

Long

Dong

et al. 2019

J of Applied Polymer Sci

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The bamboo fiber (BF)-reinforced polylactic acid (PLA) composites were prepared using the twin-screw extruder and injection molding. Thermal gravimetric analyzer results indicated the thermal stability of BF/PLA composites decreased with increasing BF content. Differential scanning calorimeter and X-ray diffraction curves showed that BF played a role as a nucleating agent, but the crystallinity of composite materials decreased with the increasing BF content. The melt flow rate of composites reduced with the increase in BF content, resulting in a poorer processing property. The processability of the composites was improved with the addition of high molecular polyethylene glycol (PEG). Mechanics performance test showed that tensile strength and bending strength of composites increased at low loading with the BF content increased then decreased when the loading continued to increase. The tensile strength of the composite materials reached 65.46 MPa when alkali-treated BF (ABF) content was 20 wt %. The flexural strength of the composites reached 97.94 MPa when ABF content was 10 wt %. Impact performance has also been improved. PEG-20000 was the best plasticizer among the PEG-6000，PEG-10000, and PEG-20000. When the component of PEG was 10 wt %, the elongation increased by 56%. The scanning electron microscopy (SEM) result showed that the fracture of the composites was smooth, most ABF were wrapped in matrix and distribution of ABF in PLA matrix was more uniform. It means that interfacial compatibility of bamboo fiber and PLA improved after BF modified by alkali. High molecular weight PEG enhance melt flow ability of polymer, result in fibers were further enclosed in the PLA matrix and increase properties of composites.

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Section: Introductionmentioning

confidence: 99%

Effect of polyethylene glycol on mechanical properties of bamboo fiber‐reinforced polylactic acid composites

Long

Dong

et al. 2019

J of Applied Polymer Sci

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“…The main appeal of electrospinning, aside from the simplicity of the equipment required, is the tunability of the method, allowing the generation of fibers from as small as tens of nanometers to several micrometers with a wide array of morphologies. In biomedical applications, recent work has utilized electrospun polycaprolactone/gelatin composite materials for guided bone regeneration, drug delivery in soft tissue, and wound dressings based on biodegradable polymers such as polyetherimide, polylactic acid, and others . In electrochemistry, electrospun materials are being employed in a range of devices, such as lithium‐ion battery separators .…”

Section: Introductionmentioning

confidence: 99%

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Kok

Jervis

Brett

et al. 2018

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Electrospun custom made flow battery electrodes are imaged in 3D using X-ray computed tomography. A variety of computational methods and simulations are applied to the images to determine properties including the porosity, fiber size, and pore size distributions as well as the material permeability and flow distributions. The simulations are performed on materials before and after carbonization to determine the effect it has in the internal microstructure and material properties. It is found that the deposited fiber size is constantly changing throughout the electrospinning process. The results also show that the surfaces of the fibrous material are the most severely altered during carbonization and that the rest of the material remained intact. Pressure driven flow is modeled using the lattice Boltzmann method and excellent agreement with experimental results is found. The simulations coupled with the material analysis also demonstrate the highly heterogeneous nature of the flow. Most of the flow is concentrated to regions with high porosity while regions with low porosity shield other pores and starve them of flow. The importance of imaging these materials in 3D is highlighted throughout.

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“…The migration behavior of L929 cells treated with different samples was assessed through the wound healing assay . The matrices samples were sterilized by UV‐light for 24 h. L929 cells were seeded in a 6 well TCPs plate with a density of 3 × 10 5 cells per well and incubated at 37 °C in 5% CO 2 in a humidified atmosphere till confluent and formation of monolayers.…”

Section: Methodsmentioning

confidence: 99%

Engineering On‐Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro‐Scale Printing

et al. 2019

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Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core-shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core-shell fibers. In addition, adding iron oxide (Fe 3 O 4 ) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3 O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3 O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

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Synthesis and characterization of curcumin loaded PLA—Hyperbranched polyglycerol electrospun blend for wound dressing applications

Cited by 154 publications

References 44 publications

Effect of polyethylene glycol on mechanical properties of bamboo fiber‐reinforced polylactic acid composites

Effect of polyethylene glycol on mechanical properties of bamboo fiber‐reinforced polylactic acid composites

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Engineering On‐Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro‐Scale Printing

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