Engineering On‐Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro‐Scale Printing

Abstract

Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core-shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core-shell fibers. In addition, adding iron oxide (Fe 3 O 4 ) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3 O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3 O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

Advances in Coaxial Additive Manufacturing and Applications

“…Coaxial additive manufacturing has been also employed in cardiac tissue engineering to restore damaged tissues as well as establishing platforms for drug screening. [46,47,51,[58][59][60][61][62] To this end, Zhu et al [59] incorporated GelMA-coated gold nanorods (G-GNR) into a bioink based on gelatin methacryloyl (GelMA). The G-GNR/GelMA ink was made by integrating G-GNRs at different concentrations into a 7% GelMA prepolymer solution.…”

“…Pull processes are based on the use of an extremely powerful electric field that pulls a meniscus and droplets from a pressure‐controlled tube to deposit material. [ 3,14 ]…”

“…In FFF, heat is normally used to partially melt feed material in a small, portable chamber whereas DIW is based on the extrusion of a liquid-phase "ink" or paste-like material through a nozzle.Pull processes are based on the use of an extremely powerful electric field that pulls a meniscus and droplets from a pressure-controlled tube to deposit material. [3,14] Coaxial AM offers numerous advantages including the combination of the properties of different materials in a single step fabrication process and the fabrication of hollow structures with often a high geometrical resolution. Moreover, coaxial AM can be used to overcome the limitations of AM regarding certain types of material.…”

3D Printing of n‐Al/Polytetrafluoroethylene‐Based Energy Composites with Excellent Combustion Stability

“…[37,38] The application of thermite in 3D printing of microenergy devices has attracted a lot of attention because of its excellent thermal properties. [39,40] Due to the complexity of fluoropolymer reaction in microsize, the specific reaction mechanism of the Al-F reaction is still under study. [41] Padhye et al [42] modeled aluminum-fluorine The development of 3D printing technology provides a new idea for the application of energy-containing materials as functional reactive materials, which helps Al-F high-energy materials to achieve customized performance and structure, so that energy transmit can be targeted.…”

“…[ 37,38 ] The application of thermite in 3D printing of microenergy devices has attracted a lot of attention because of its excellent thermal properties. [ 39,40 ]…”