“…The Cu (II) ion is a bioactive metal and essential micronutrientwith a narrow range of biological toxicity that, coordinated with ligands, is transported to the intracellular environment and causes in situ oxidative stress reactions with the production of free radicals and oxidant species (ROS), as well as disorganization of the peritrophic matrix and destruction of the intestinal microvilli of mosquito larvae (Arruda et al 2010, Gopinathan and Arumugham 2014, Nardeli et al 2014, Gaban et al 2015. In addition, it is a powerful antimicrobial agent that if used as a contact surface for metal alloys, inactivates microorganisms such as Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus (Neciosup et al 2015).…”