Copper II - polar amino acid complexes: toxicity to bacteria and larvae of Aedes aegypti

Abstract

Control strategies using insecticides are sometimes ineffective due to the resistance of the insect vectors.In this scenario new products must be proposed for the control of insect vectors.The complexes L-aspartate Cu (II) and L-glutamate-Cu (II) complexes were synthesized and characterized by elemental analysis, visible ultraviolet, infrared spectroscopy and potentiometric titration. The toxicity of these complexes was analyzed in Aedes aegypti (Diptera: Culicidae) larvae and Gram-negative and Gram-positive bacteria. The interaction between the ligands and the amino acid balance and the distribution of the species as a function of pH were discussed. The lethal concentration median (LC 50 ) for Ae. aegypti larvae were: L-glutamic acidCu (

Serine-Modified Au@Cu2O Core–Shell Nanoparticles for Catalysis-Mediated Colorimetric Detection of Small Molecules

“…On the basis of the concept of alternative click-chemical pairing of amino acids and blood ketones (Figure a), serine was selected to modify the Au@Cu 2 O NCs and thus functionalize them to specifically target nonvolatile βHBA and volatile acetone. Serine has innate coordination with metal; the carboxylic acid group in serine could conjugate with surface-exposed Cu + sites on the Au@Cu 2 O NC through monodentate chelation . Therefore, the Au@Cu 2 O-s NCs had exposed hydroxyl and 1° amine functional groups, enabling a strong interaction with βHBA to form an amide bond.…”

“…Serine has innate coordination with metal; the carboxylic acid group in serine could conjugate with surface-exposed Cu + sites on the Au@Cu 2 O NC through monodentate chelation. 39 Therefore, the Au@Cu 2 O-s NCs had exposed hydroxyl and 1°a mine functional groups, enabling a strong interaction with βHBA to form an amide bond. Moreover, the Au@Cu 2 O-s NCs exposed to amine could also react with acetone, forming imine bonds.…”

From Metal Complexes to BioMOFs: An Experimental Proposal for Teaching Coordination Chemistry Concepts

“…MOFs (BioMOFs or MBioFs) and metal complexes containing glutamic acid have several applications, such as adsorbents, , catalysts, ,, and antimicrobial agents. , The purpose of this work is to present an experimental activity in inorganic chemistry at the undergraduate level that involves transition metals from d 5 to d 10 systems combined with glutamic acid to obtain BioMOFs and metal complexes. These synthesis processes are carried out from the same class of reagents, allowing the approach of traditional concepts of coordination chemistry, such as crystal field splitting, the chelate effect, Pearson acidity/basicity, Jahn–Teller distortion, stability series, and BioMOF class presentation, in addition to practicing interdisciplinarity with knowledge of the amino acid structures, their p K a values, and their different ways of acting as ligands.…”

Nanometer‐sized, rod‐like, ligand‐containing tryptophan complexes: Anion influence–structural geometry–antitumor activity correlations

“…[ 9 ] Therefore, metal complex–based proteinogenic α ‐amino acid ligands have become a hot research topic, 10 and the efforts resulted in a wide pharmacological spectrum, including anti‐inflammatory and anticonvulsant properties [ 11 ] in addition to efficient biological and cytotoxic activities. Furthermore, the low production cost and low environmental toxicity of α ‐amino acid complexes [ 12 ] directed efforts for studying metalloprotein systems. [ 13 ] In this respect, l ‐tryptophan is an important component of proteins and vital in human nutrition for sustaining positive nitrogen balance.…”