Synthesis and application of hydroxyapatite/polylactide composite biomaterial

Ignjatović, Nenad; Uskokovic, Dragan

doi:10.1016/j.apsusc.2004.05.227

Cited by 90 publications

(52 citation statements)

References 16 publications

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“…Moreover, aliphatic polyesters are lack of osteoconductivity and osteoinductivity so that it is hard for the new bone tissue bond on the materials surface tightly [8]. To overcome these limitations, many kinds of inorganic particles such as hydroxyapatite (HAP), -tricalcium phosphate, clay, magnesia (MgO) and titanium dioxide, etc., have been introduced into the aliphatic polyester matrix [9][10][11][12][13][14][15]. However, the mechanical strength and elastic modulus of polymer matrix may be improved by introduction of a certain amount of inorganic particles, but the particles also may cause stress concentration which results in the decrease of the toughness for particle-filled polymer.…”

Section: Introductionmentioning

confidence: 97%

Strengthening and toughening of poly(L-lactide) composites by surface modified MgO whiskers

Wen

Luo

Qin

et al. 2015

Applied Surface Science

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Section: Introductionmentioning

confidence: 97%

Strengthening and toughening of poly(L-lactide) composites by surface modified MgO whiskers

Wen

Luo

Qin

et al. 2015

Applied Surface Science

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“…They demonstrated good adhesion and expression of cells responsible for bone regeneration on the surface of the ceramic-polymer biomaterial [36,37,38].…”

Section: Discussionmentioning

confidence: 99%

Ceramic-polylactide composite material used in a model of healing of osseous defects in rabbits

Myciński¹,

Zarzecka²,

Skórska-Stania³

et al. 2017

pjp

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“…Therefore, before conducting formal medical tests, the performance of the tool was investigated during experiments on artificial materials with elastic moduli similar to those of calcified plaque and normal arteries. Hydroxyapatite/polylactide (HA/PLA) composite has been investigated as possible material for implants or bone substitutes, since HA is a main component of bone, and PLA is a biocompatible polymer that degrades inside the human body (Ignjatovic et al 1999;Ignjatovic and Uskokovic 2004). HA/PLA composite was used in this research because of the high HA content of calcified plaque.…”

Section: Ablation Experiments Materialsmentioning

confidence: 99%

A rotational ablation tool for calcified atherosclerotic plaque removal

Kim¹,

Kim²,

Kim³

et al. 2011

Biomed Microdevices

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Atherosclerosis is a major cardiovascular disease involving accumulations of lipids, white blood cells, and other materials on the inside of artery walls. Since the calcification found in the advanced stage of atherosclerosis dramatically enhances the mechanical properties of the plaque, restoring the original lumen of the artery remains a challenge. High-speed rotational atherectomy, when performed with an ablating grinder to remove the plaque, produces much better results in the treatment of calcified plaque compared to other methods. However, the high-speed rotation of the Rotablator commercial rotational atherectomy device produces microcavitation, which should be avoided because of the serious complications it can cause. This research involves the development of a high-speed rotational ablation tool that does not generate microcavitation. It relies on surface modification to achieve the required surface roughness. The surface roughness of the tool for differential cutting was designed based on lubrication theory, and the surface of the tool was modified using Nd:YAG laser beam engraving. Electron microscope images and profiles indicated that the engraved surface of the tool had approximately 1 μm of root mean square surface roughness. The ablation experiment was performed on hydroxyapatite/polylactide composite with an elastic modulus similar to that of calcified plaque. In addition, differential cutting was verified on silicone rubber with an elastic modulus similar to that of a normal artery. The tool performance and reliability were evaluated by measuring the ablation force exerted, the size of the debris generated during ablation, and through visual inspection of the silicone rubber surface.

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Synthesis and application of hydroxyapatite/polylactide composite biomaterial

Cited by 90 publications

References 16 publications

Strengthening and toughening of poly(L-lactide) composites by surface modified MgO whiskers

Strengthening and toughening of poly(L-lactide) composites by surface modified MgO whiskers

Ceramic-polylactide composite material used in a model of healing of osseous defects in rabbits

A rotational ablation tool for calcified atherosclerotic plaque removal

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