“…As a part of our ongoing studies on the coordination and biological chemistry of palladium(II) compounds (da Silva et al, 2014;Ferreira et al, 2012;Mauro et al, 1999; Netto et al, 2001Netto et al, , 2005Santana et al, 2001Santana et al, , 2011, we have synthesized the new iodo-derivative [Pd(C 2 ,N-dmba)(I)(tu)] from the cleavage reaction involving the precursor [Pd(C 2 ,N-dmba)(l-I)] 2 and thiourea ligand aiming at investigating whether the increase of the anion softness would result in an enhancement of the cytotoxic activity against murine tumor cell lines (LM3 and LP07) and Mycobacterium tuberculosis. In addition, we have also evaluated the mutagenic potential of the organometallic [Pd(C 2 ,N-dmba)(l-X)] 2 and [Pd(C 2 ,Ndmba)(X)(tu)] compounds (X = Br, I) by the Ames test.…”