Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

Medicinal Plants as Therapeutic Alternatives to Combat Mycobacterium tuberculosis: A Comprehensive Review

“…Recently, deaths achieved by TB crossed the number of deaths caused by human immunodeficiency infection (HIV) and gastrointestinal infections together. It is widely believed that over the past two centuries, TB killed one billion people [ 12 ].…”

Recent advancement in drug development of nitro(NO2)‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis

“…However, few of these molecules were tested against infectious diseases (e.g. TB; Scarim et al, 2021a; Thompson, Blaser, et al, 2017). This review article attempts to describe the majority of nitro‐based analogues that have been tested against Mtb and other infectious diseases.…”

The synthesis and antibacterial activity study of ruthenium-based metallodrugs with a membrane-disruptive mechanism against Staphylococcus aureus

“…12,13 Metal-based complexes acting as antibacterial agents have received widespread attention in recent years, many of these compounds showing potential for inhibiting multidrug-resistant strains. [14][15][16][17][18] It is reported that ruthenium complexes can irreversibly inhibit metallo-β-lactamase, which contributes to tackling the clinical crisis of carbapenem-resistant bacteria. 19 Arene ruthenium compounds incorporating indole-containing ligands exhibited broad-spectrum antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria, including antibiotic-resistant bacteria.…”