Mono-and binuclear cyclometallated Pd(II) compounds containing C,N-chelating dimethylbenzylamine (Hdmba) have been synthesized aiming at investigating their mutagenic properties (Ames test) and cytotoxic activity toward murine tumor cell lines and Mycobacterium tuberculosis. By reactions of [Pd(C 2 ,N-dmba)(l-X)] 2 {X = Br (1), I (2)} with thiourea (tu), in the 1:2 molar ratio, the mononuclear compounds [Pd(C 2 ,N-dmba)(X)(tu)] {X = Br (3), I (4)} were readily obtained. The new compound 4 was characterized by elemental analyses, infrared (IR) and 1 H-and 13 C{ 1 H}-NMR spectroscopies. The cytotoxicity assessment of the cyclopalladated compounds 1-4 revealed that the iodo-derivative 4 was the most active toward murine mammary adenocarcinoma (LM3) cells, even more effective than cisplatin. The cyclometallated compounds 1-4 did not demonstrate mutagenic potential according to Ames test results. Compound 4 was only moderately active (MIC = 60 lg mL -1 ) against M. tuberculosis. Graphical Abstract Mono-and binuclear cyclopalladated compounds have been synthesized. These complexes displayed cytotoxic levels toward murine mammary adenocarcinoma cells comparable to cisplatin. Cyclopalladated compounds were non-mutagenic in the Ames test, contrary to cisplatin and its analogues.

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Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity, Polyhedron (2015), doi: http://dx.Abstract Complexes of the type trans-[PdCl 2 (HL)(PPh 3 )], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh 3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and 1 H-NMR spectroscopies. Single-crystal X-ray diffraction determination on 3·0.9 CHCl 3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a Minimum Inhibitory Concentration (MIC) of 7.61 ± 2.18 µM, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes.