Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

Abstract

Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity, Polyhedron (2015), doi: http://dx.Abstract Complexes of the type trans-[PdCl 2 (HL)(PPh 3 )], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh 3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and 1 H-NMR spectroscopies. Single-crystal X-ray diffraction determination on 3·0.9 CHCl 3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a Minimum Inhibitory Concentration (MIC) of 7.61 ± 2.18 µM, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes.

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

“…A series pyrazolyl-based Pd(II) complexes were synthesized by Da Silva et al and evaluated in vitro for antimycobacterial activity. Anti-tuberculosis evaluation demonstrated that compound 367 displayed excellent activity with MIC of 7.61 µM [ 266 ]. A novel aminopyrazolo[1,5- a ]pyrimidine derivatives were synthesis by Street et al and tested for their anti-mycobacterial activity.…”

Halogen-bonded network of trinuclear copper(II) 4-iodopyrazolate complexes formed by mutual breakdown of chloroform and nanojars

“…A search of the Cambridge Structural Database (Groom et al, 2016) reveals only seven metal complexes that contain a 4-iodopyrazole moiety, either in its neutral, monodentate form (Guzei & Winter, 1997;Govor et al, 2012;Song et al, 2013;da Silva et al, 2015), or in its deprotonated, bidentate form (Heeg et al, 2010;Song et al, 2013). Of these, only one is a Cu II complex (Song et al, 2013 Halogen-bond geometry (Å , ).…”