Overview on Biological Activities of Pyrazole Derivatives

Kabi, Arup K.; Sravani, Sattu; Gujjarappa, Raghuram; Garg, Aakriti; Vodnala, Nagaraju; Tyagi, Ujjawal; Kaldhi, Dhananjaya; Singh, Virender; Gupta, Shikhar; Malakar, Chandi C.

doi:10.1007/978-981-16-8399-2_7

Cited by 4 publications

(2 citation statements)

References 344 publications

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“…Pyrazoles substituted with sulfur moieties are known to exhibit diverse and significant pharmacological activities, which represent them as an essential class of organosulfur compounds. [77][78][79] The C-4 substituted pyrazoles with sulfur fragments are particularly important. [80,81] There have been various reports previously published for this kind of transformation involving the use of ligand, palladium catalyst, riboflavin-derived alloxazinium salt (4-TfO), DMSO in specific equivalents and catalytic amounts of iodine with or without the support of TBHP oxidant (Scheme 8 (a), (b), (f), (c), (d) and (e)).…”

Section: Csp 2 à S Bond Formationmentioning

confidence: 99%

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Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis

Reetu,

Kalita,

Dash

et al. 2024

ChemistrySelect

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Organic synthesis involves the production of important chemical structures using scalable and cost‐effective methods that are also environmentally friendly. In this review, a detailed analysis of the use of iodine and DMSO in various synthetic routes for the preparation of valuable targets are presented. These methods reduce the acceptance on expensive additives and reagents, and offer a more sustainable solution for the synthesis of these important chemical scaffolds.

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Section: Csp 2 à S Bond Formationmentioning

confidence: 99%

Section: C−s Bond Formationmentioning

confidence: 99%

Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis

Reetu,

Kalita,

Dash

et al. 2024

ChemistrySelect

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HFIP‐Mediated Cyclodesulfurization Approach for the Synthesis of 2‐Aminobenzoxazole and 2‐Aminobenzothiazole Derivatives

Kant,

Patel,

Banerjee

et al. 2024

Asian J Org Chem

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A straightforward strategy for the synthesis of pharmaceutically active 2‐aminobenzoxazoles and 2‐aminobenzothiazoles is described by using 2‐aminophenols, 2‐aminothiophenols, and functionalized phenylisothiocyanates as the model substrates. The developed method proceeds through the HFIP‐promoted cyclodesulfurization process which allows for the efficient synthesis of these scaffolds at 60 °C of reaction temperature without the addition of a transition metal‐catalyst or hazardous solvents with excellent yields (up to 92%) of product formation. This process involves HFIP‐mediated hydrogen bonding interactions with the hydroxyl and thiol moieties, leading to bond breaking and formation during the reaction, resulting in the compounds of interest and the in situ release of H2S gas.

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Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles

Kant,

Patel,

Banerjee

et al. 2023

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Nitrogen‐containing heterocycles such as imidazoles, thiazoles, and oxazoles play a significant role in the fields of biological and pharmaceutical chemistry. These compounds were widely used for agrochemical, pesticide, medicinal, and industrial applications. Due to the wide spectrum of structural diversity as well as the biological and pharmaceutical activity of N‐heterocycles, a plethora of reports on their synthesis have appeared in the last few decades. However, developments in various bond‐forming strategies such as C−C, C−N, C−O, C−S, and N−N, as well as C−H activation, have been used as a powerful synthetic tool to derive copious N‐heterocycles. The most prominent and fascinating reports on the synthesis of imidazole, thiazole, oxazoles, and benzimidazole moieties by C−C and C−N coupling reactions, multi‐component and cycloaddition reactions, C−H activation, etc. are discussed in this study. These studies demonstrated the enormous potential of such methods for accelerating modern chemical synthesis and establishing molecular beauty through bonding. The various aspects of the methodologies, like optimized conditions, substrate scope, and mechanistic investigations, are discussed in detail.

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Overview on Biological Activities of Pyrazole Derivatives

Cited by 4 publications

References 344 publications

Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis

Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis

HFIP‐Mediated Cyclodesulfurization Approach for the Synthesis of 2‐Aminobenzoxazole and 2‐Aminobenzothiazole Derivatives

Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles

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