Synthesis and Antibacterial Activity of Novel Vanillic Acid Hybrid Derivatives

Satpute, Maruti S.; Gangan, Vijay D.; Shastri, Indu

doi:10.31788/rjc.2019.1215023

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…The methanol extract of E. elatior fruit contains bioactive compounds such as flavonoids, tannins, saponins, steroids, and triterpenoids [10]. The results of the study by Satpute et al reported that VA has antimicrobial, anti-inflammatory, and antioxidant properties [11]. In vitro studies showed that VA of 100 g/ml can inhibit the growth of S. enterica and S. mutans bacteria [12].…”

Section: Methodsmentioning

confidence: 99%

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Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Nurhayatun

Chitra²

2022

IOP Conf. Ser.: Earth Environ. Sci.

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Sepsis is the consequence of widespread inflammation in the body. Inflammation and blood clotting during sepsis cause reduced blood flow to vital organs which can lead to organ failure and even death. Kecombrang (Etlingera elatior) is proposed to have the ability to suppress inflammation and oxidative stress through the control of NF-kB. This study aims to investigate the effect of the extract of Kecombrang fruit on the level of NF-kB in Mus musculus sepsis model. This laboratory experimental study was conducted on a total of 20 Mus musculus which were equally divided into four groups. Group received lipopolysaccharide (LPS) induction as the control group. MP1 group received LPS induction and pretreated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for 5 days before induction of LPS. MP2 Group received LPS induction and treated with methanol extract of Kecombrang fruit (4.2 mg/20 gr) for 5 days after induction of LPS. MP3 group received LPS induction and treated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) at the same time of LPS induction. The measured outcome was the serum level of NF-kB. Data were analyzed using ANOVA with p <0.05. Pretreated extracts of Kecombrang fruit significantly decrease the serum levels of NF-kB (p<0.05). The beneficial effects of extracts of Kecombrang fruit in sepsis are evident from the observations. It means that the extract of Kecombrang can be exploited in the treatment of sepsis.

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Section: Methodsmentioning

confidence: 99%

“…The results of the study by Satpute et al reported that VA has antimicrobial, anti-inflammatory, and antioxidant properties [11]. In vitro studies showed that VA 100 g/ml can inhibit the growth of S. enterica and S. mutans bacteria [12].…”

Section: Introductionmentioning

confidence: 99%

Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Nurhayatun

Chitra²

2022

IOP Conf. Ser.: Earth Environ. Sci.

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“…Many vanillic acid derivatives were produced and evaluated for different biological activities; vanillic Acid-oxadiazole Schiff bases showed interesting antibacterial activity (20) , novel ester-hybrid derivatives of vanillic acid examined for their antibacterial activity, the methyl vanillate derivative has significant anti-bacterial activity against tested Gram-positive and Gram-negative bacteria (21) . Other series of amide derivatives of vanillic acid exhibit promising selective inhibitory effects against α-amylase, and α-glucosidase enzymes (19) .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Preliminary Evaluation of Antimicrobial activity of Imines derived from Vanillic Acid Conjugated to Heterocyclic

Sabzi,

Mohammed Jawad

2023

IJPS

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The purpose of this research is to prepare new vanillic acid derivatives with 1,2,4-triazole-3-thiol heterocyclic ring and evaluate their antimicrobial activity in a preliminary assessment. A multistep synthesis was established for the preparation of new vanillic acid-triazole conjugates. The intermediate of 4-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-2-methoxyphenol (4) reacts with different heterocyclic aldehydes (thiophene-2-carboxaldehyde, pyrrole-2-carboxaldehyde, thiophene-3-carboxaldehyde, and furfural ) in ethanol containing few drops of acetic acid yielded the corresponding 4-(4-(substituted amino)-5-mercapto-4H-1,2,4-1triazol-3-yl)-2-methoxy phenol derivatives (5-8). These compounds were characterized spectroscopically by FT-1IR and 1H-1NMR. These imine derivatives (5-8) were tested for their antimicrobial activity and compared with three different standard references (amoxicillin, ciprofloxacin, and fluconazole). Overall, compounds 6 and 8 exhibited varying degrees of inhibitory effects on the growth of the examined bacterial species and fungus. The most active one is compound 6 having pyrrole ring imine derivative showed potent activity against C. 1albicans and moderate activity against all tested bacteria compared to other derivatives but no activity toward P. 1aeruginosa and P. 1mirabilis.

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“…Research in the internal medicine department of RSUD Dr. Moewardi Surakarta in 1997 found that 130 (97%) out of 135 sepsis patients died [8]. In 2004, the mortality rate due to sepsis in RSUD Dr. Moewardi Surakarta reached 74 (83.1%) out of 89 sepsis patients [9]. Research conducted on January 2006-December 2007 in the PICU/NICU section of RSUD Dr. Moewardi Surakarta reported the incidence of sepsis of 33.5% with a mortality rate of 50.2% [10].…”

Section: Introductionmentioning

confidence: 99%

Empirical Study of Anti-Inflammatory Effects of Kecombrang (Etlingera elatior) in Mus musculus Sepsis Model

Nurhayatun

Purwanto

Soetrisno

et al. 2022

Open Access Maced J Med Sci

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Mice used as experimental animals in the laboratory belong to the genus Mus, subfamily Murinae, family Muridae, superfamily Muroidea, order Rodentia, and class M. musculus , these mice are also referred to as home mice. Mice have been used as standard animals in toxicology, teratology, and carcinogenesis tests, even today, mice have also been used for behavioral, neurologic, nutritional, genetic, immunological, infectious, metabolic, and degenerative disease studies. Animal models of sepsis with intraperitoneal or intravenous injection of lipopolysaccharide (LPS) have been widely used for sepsis research. LPS induces systemic inflammation that mimics the early phase of sepsis. LPS injection causes kidney injury, including a decrease in glomerular filtration rate, an increase in blood urea nitrogen, and an increase in neutrophil infiltration in the kidney. The injectable dose of LPS can be titrated to mimic early sepsis without hemodynamic compromise, which has been useful for studying the systemic and renal responses. The response during the early phase of sepsis is that doses of LPS are usually used to induce systemic hypotension and decrease glomerular perfusion, whereas low doses of LPS do not cause systemic hypotension but still decrease glomerular perfusion. There are several advantages of LPS compared to others, namely, the method used is simple and the model is very controlled and standardized. The dose of endotoxin that causes 50% mortality in mice is 1–25 mg/kg. In this study, mice were given intraperitoneal injection of LPS at a dose of 0.3 mg/kg BW. LPS injection was given to the positive control group and treatment group 1, treatment group 2, and treatment group 3 at the start of the study.

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Synthesis and Antibacterial Activity of Novel Vanillic Acid Hybrid Derivatives

Cited by 8 publications

References 7 publications

Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model

Synthesis, Characterization, and Preliminary Evaluation of Antimicrobial activity of Imines derived from Vanillic Acid Conjugated to Heterocyclic

Empirical Study of Anti-Inflammatory Effects of Kecombrang (Etlingera elatior) in Mus musculus Sepsis Model

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