Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing

Abstract

Gold-loaded nanoparticles are versatile nanomaterials that may be used in wound healing properties. The current study describes a wound dressing formulation focused on Gold-loaded Dextran/Silk Sericin nanoparticles. The Gold-loaded Dextran/Silk Sericin membranes were fabricated using Gold solutions inside the Dextran/Silk Sericin medium. The influence of various experimental conditions on Dextran/Silk Sericin nanoparticle formations were examined. The sizes of Dextran/Silk Sericin and Gold@Dextran/Silk Sericin nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of Dextran/Silk Sericin and Gold-loaded Dextran/Silk Sericin nanoparticles was evaluated against the microorganisms gram-positive and negative. Furthermore, we observed the in vivo wound healing of wounds in skin using a mice model over a 16 days period. In this difference to the wounds of untreated mouse, quick healing was observed in the Gold-loaded Dextran/Silk Sericin nanoparticles-treated wounds with fewer injury. These results specify that Gold-loaded Dextran/Silk Sericin nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound damages, which was proven using an animal model.

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

“…Previous studies have revealed that natural SS act as reducing (the carboxylic acid group) and stabilizing agents for metal NPs and are environmentally friendly [ 74 , 90 ]. Silver (Ag), gold (Au), and zinc (Zn) nanoparticles have been widely used to prepare antibacterial SS composite materials [ 30 , 31 , 75 ]. The SS materials loaded with metal NPs effectively inhibit the skin-infecting bacteria, including E. coli , P. aeruginosa and S. aureus [ 30 , 32 , 66 , 68 , 91 ].…”

“…Anti-infection is a crucial task in the wound-healing process, especially for some chronic wounds. To enhance the antimicrobial properties of SS materials, different antimicrobial agents, including metal nanoparticles, natural antimicrobials, and antibiotics, have been incorporated into the composites, which have significantly promoted wound healing [ 30 , 34 , 37 , 64 , 66 , 75 , 81 , 82 ]. Moreover, some studies have demonstrated the anti-inflammatory effects of SS alone [ 142 ].…”

“…SS composites loaded with various metal nanoparticles can promote wound healing by inhibiting common chronic wound bacteria [ 30 , 37 , 75 ]. Sodium alginate, different concentrations of AgNO 3 , and calcium gluconate were sequentially added to SS, mixed thoroughly, and placed under natural light for 24 h at 25 °C to obtain SA/Se-Ag hydrogels [ 30 ].…”

How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature

“…Animal experimental results showed that wound healing was significantly accelerated and scar formation was significantly reduced. 138 Although AuNPs can inhibit bacterial growth and promote wound healing, more often AuNPs is used in combination with other antibacterial substances or particles. Li et al constructed a chitosan wound dressing embedded with Au-Ag nanoparticles, and compared with CS-Ag without Au, the antibacterial effect of CS-Au-Ag was significantly enhanced.…”

Effectiveness of Copper Nanoparticles in Wound Healing Process Using In Vivo and In Vitro Studies: A Systematic Review

“…However, gold nanoparticles (AuNPs) containing polycaprolactone nanofibers have a limited antibacterial action against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans (zone of inhibition values less than 3 mm) [12]. Furthermore, while AuNPs have the ability to limit bacterial growth and promote wound healing, they should be utilized in conjunction with other antibacterial chemicals or particles [13,14].…”