Chronic wounds are defined as wounds that fail to proceed through the normal phases of wound healing in an orderly and timely manner. The most common and inevitable impairment to wound healing is the installation of an infection, usually in the case of chronic wounds. Therefore, the objective of the present review was to identify the importance of copper nanoparticles in dressings for wound healing. Nanoparticles such as silver, gold and copper combat infectious processes through the inhibition of protein synthesis, peroxidation of the cell membrane and destroying the nucleic acids of bacteria and viruses. Among bioactive nanoparticles, copper plays a complex role in various cells, it modulates several cytokines and growth factor mechanisms of action and is essentially involved in all stages of the wound healing process. More importantly, copper plays a key role in skin regeneration and angiogenesis and accelerates the healing process through induction of vascular endothelial growth factor (VEGF) and angiogenesis by hypoxia-induced factor-1-alpha (HIF-1α) action where copper enhances HIF-1α expression and HIF-1α binding to the critical motifs in the promoter and putative enhancer regions of HIF-1-regulated genes.
INTRODUCCIÓNLa miel es definida como una sustancia dulce, no fermentada, producida por las abejas (Apis mellifera) que recogen y procesan el néctar de las flores o de las secreciones de ciertas especies de plantas. Las abejas, transforman y combinan esta sustancia con otras específicas propias que finalmente almacenan y maduran en panales.Los beneficios de la miel se conocen desde hace miles de años y ha sido utilizada en la antigüedad por su valor nutritivo y medicinal. Las primeras evidencias del consumo de la miel aparecen en pinturas rupestres del Mesolítico, unos 6.000 años A.C. y su uso como medicamento unos 2.500 años A.C. por los sumerios en Mesopotamia. Entre los usos médicos, desde la antigüedad la miel ha servido en el cuidado de heridas. Los antiguos egipcios, los asirios, los chinos, los griegos y los romanos utilizaban la miel para tratar heridas. En los papiros de Eberts y Smith, que datan de 1500 A.C. ya se aconsejaba tratar con miel las heridas. Hipócrates, en su obra "Consideraciones sobre el tratamiento de las heridas", recomienda curarlas con miel (Al-Waili et al., 2011;Tan et al., 2012;Eteraf-Oskouei & Najafi, 2013;Zbuchea, 2014;Jull et al., 2015).Después de haber cumplido un papel importante en la tradición médica de muchos pueblos, la miel fue "redescubierta" por la medicina moderna debido a sus importantes propiedades bactericidas en heridas infectadas con bacterias multiresistentes a los antibióticos (Godebo et al., 2013;Melake et al., 2015). Desde entonces, numerosos estudios han centrado su interés en demostrar que las propiedades biológicas y físicas de la miel le confieren una gran eficacia en el tratamiento de heridas de diversas etiologías (Al-Waili et al.; Jull et al.) y que su uso ofrece un tratamiento natural alternativo en la población mundial que reducen el costo de RESUMEN: Los beneficios de la miel de abeja (Apis mellifera) se conocen desde hace miles de años y ha sido utilizada en la antigüedad por su valor nutritivo y medicinal siendo "redescubierta" por la medicina moderna debido a sus importantes propiedades antibacterianas en heridas infectadas. Nuevos estudios han argumentado a favor de la capacidad de la miel para interactuar con la compleja maquinaria celular y llevar a cabo la reparación de los tejidos. Por este motivo, se realizó una revisión de los contenidos actuales de las propiedades de la miel y su rol en los procesos morfofisiológicos de reparación de heridas. De esta manera se abarcó la acción antibacteriana, anti-oxidante y anti-inflamatoria de sus componentes. Así mismo, se revisaron las propiedades físicas y de desbridamiento, la importancia del origen floral y ubicación geográfica en el valor medicinal de los diferentes tipos de miel. Los estudios sugieren que los efectos de la miel son el resultado de una actividad combinada, donde sus componentes interactúan de manera sinérgica para lograr su función terapéutica. Su acción la realiza en todas las etapas del proceso morfofisiológico de reparación logrando acelerar la cicatrización de heridas. El orige...
BackgroundIn the context of the search for cost-efficient treatments, Ulmo (Eurcyphia cordifolia) honey is an excellent alternative for treating burn wounds and could have a profound medical, social, and economic impact. Ascorbic acid is an enzymatic co-factor necessary for the synthesis of collagen and the proliferation of fibroblasts and has been proposed as a coadjuvant to strengthen the healing effects of honey. The aim of this work was to evaluate by morphometric studies the healing wounds caused by burns treated with Ulmo honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus).MethodsFifteen guinea pigs were used and divided randomly into three groups: positive control (C+), experimental with unsupplemented honey (H), and experimental with supplemented honey (SH). A uniform deep burn covering 1 cm2 of the back skin was performed. The following indices were calculated for the morphometric study: superficial contraction index of the wound, deep contraction index of the wound, wound severity index, global healing index, global contraction index, and dermal proliferation area.ResultsThe superficial contraction index of the wound, global healing index, global contraction, and dermal proliferation area values of the experimental with supplemented honey group were higher than the other groups (P < 0.05).ConclusionsAccording to these results, the combination of honey with an antioxidant (ascorbic acid) promotes an appropriate action to support the healing effect. This study showed that by supplementing the Ulmo honey with ascorbic acid, the healing and contraction effects can be strengthened in burn wounds compared to unsupplemented honey. These results were proof of the synergy between honey and ascorbic acid in healing burn wounds.
The aim was to analyze histologically the bone repair in a mandibular osteotomy model with different gaps between the segments. Nine male rabbits who underwent osteotomies on the mandibular body were fixed with a 1.5 system plate and no bone graft; group 1 (2 mm gap between segments), group 2 (5 mm gap between segments), and group 3 (8 mm gap between segments) were included. After 8 weeks they were euthanized and the sample was processed for histological analysis. Group 1 showed advanced bone repair with cartilaginous tissue and cancellous bone, showing osteoblasts and type III collagenous fibers. In group 2, a more delayed ossification was observed, with an extensive area of peripheral ossifying cartilage and chondrocytes in greater number at the center of the defect; group 3 showed no evidence of ossification with fibrous tissue, a very low level of chondrocytes, and some bone sequestrate. We can conclude that, in this animal model, 2 or 5 mm gap in the osteotomy could be repaired as bone when fixation is used. The size of the gap is an important factor for the use of bone grafts considering endochondral ossification. This model can be used for graft analysis and related technologies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.