How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature

Wang, Feng; Zhang, Wenyao; Li, Hao; Chen, Xiaonan; Feng, Sining; Mei, Ziqing

doi:10.2147/ijn.s361282

Cited by 21 publications

(15 citation statements)

References 185 publications

(154 reference statements)

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“…Multitudes of nanotherapeutic approaches have been introduced to efficiently manage the wounds and remove any related possible complications (Figures 2 and 3) [76]. The advantage of using nanomaterials over other wound dressings is their tenability, low cytotoxicity, good biocompatibility, drug delivery ability, and versatility of physicochemical properties endowing them with many unique features [71,76,77]. Furthermore, nanoscale helps them in enhanced penetration to the injury site and a high interaction probability with the biological target [78].…”

Section: Management Of Wounds Through Nanotherapeutic Approachesmentioning

confidence: 99%

Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events

Soni¹,

Singla²,

Padwad³

2023

Wound Healing - Recent Advances and Future Opportunities

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Wound-healing cascade is highly dynamic and composed of four continuous but overlapping phases that are precisely programmed. Successful healing occurs when these phases occur sequentially in a specific time frame and thus require multipotent wound-healing material. Nanotechnology has revolutionized the field of wound dressings by the development of various types of nanotechnology-based drug delivery systems and materials to treat hard-to-heal wounds. In this chapter, the advantages and the limitations associated with nanoparticle-based wound-healing materials as well as recent trends and applications of nanotechnology-based approaches in advanced wound therapy for healing of cutaneous, chronic, and burn wounds will be detailed along with the molecular interventions involved. Efforts are targeted herein to address the most significant factors affecting cutaneous wound healing and the molecular mechanisms involved. This chapter describes several nanoparticle (NP)-based drug delivery systems to improve the healing potential of antimicrobial, antifungal, growth factors, and other bioactive agents. While much remains to be learned, a better understanding of the factors influencing wound repair and nanotechnological interventions therein may lead to therapeutics that improve the healing process.

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Section: Management Of Wounds Through Nanotherapeutic Approachesmentioning

confidence: 99%

Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events

Soni¹,

Singla²,

Padwad³

2023

Wound Healing - Recent Advances and Future Opportunities

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“…Considering that organic nanoparticles have abundant functional group structures that can better bind to drugs and GFs and the ions brought by metal nanoparticles have good antibacterial properties, they show great potential in the treatment of diabetic wounds. 23 With the advancement of society and technology, researchers have discovered nanoparticles with numerous biological properties that can be applied to diabetic wound therapy to remedy some of the drawbacks of clinical treatment. This review summarizes the recent applications of organic nanoparticles (eg, polymeric nanoparticles,…”

Section: Application Of Nanoparticles To Treat Diabetic Woundsmentioning

confidence: 99%

A Comprehensive Review of the Application of Nanoparticles in Diabetic Wound Healing: Therapeutic Potential and Future Perspectives

Qin¹,

Wu²,

Liu³

et al. 2022

IJN

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Diabetic wounds are one of the most challenging public health issues of the 21st century due to their inadequate vascular supply, bacterial infections, high levels of oxidative stress, and abnormalities in antioxidant defenses, whereas there is no effective treatment for diabetic wounds. Due to the distinct properties of nanoparticles, such as their small particle size, elevated cellular uptake, low cytotoxicity, antibacterial activity, good biocompatibility, and biodegradability. The application of nanoparticles has been widely used in the treatment of diabetic wound healing due to their superior anti-inflammatory, antibacterial, and antioxidant activities. These nanoparticles can also be loaded with various agents, such as organic molecules (eg, exosomes, small molecule compounds, etc.), inorganic molecules (metals, nonmetals, etc.), or complexed with various biomaterials, such as smart hydrogels (HG), chitosan (CS), and hyaluronic acid (HA), to augment their therapeutic potential in diabetic wounds. This paper reviews the therapeutic potential and future perspective of nanoparticles in the treatment of diabetic wounds. Together, nanoparticles represent a promising strategy in the treatment of diabetic wound healing. The future direction may be to develop novel nanoparticles with multiple effects that not only act in wound healing at all stages of diabetes but also provide a stable physiological environment throughout the wound-healing process.

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“…Despite the potentialities, some features of the hydrogels require optimization, such as mechanical properties, biological activity, and pharmacokinetic parameters of the drug incorporated in the matrix [ 13 ]. Therefore, a great deal of effort has been invested in prospecting novel approaches for overcoming these restrictions, which includes the development of hydrogels containing nanocarriers [ 17 , 18 , 19 ]. The nanoparticles can be classified according to their composition and structural organization, including hard nanoparticles, which are made of inorganic materials, and nanocarriers composed of organic materials, named soft nanoparticles [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

et al. 2023

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Wounds are alterations in skin integrity resulting from any type of trauma. The healing process is complex, involving inflammation and reactive oxygen species formation. Therapeutic approaches for the wound healing process are diverse, associating dressings and topical pharmacological agents with antiseptics, anti-inflammatory, and antibacterial actions. Effective treatment must maintain occlusion and moisture in the wound site, suitable capacity for the absorption of exudates, gas exchange, and the release of bioactives, thus stimulating healing. However, conventional treatments have some limitations regarding the technological properties of formulations, such as sensory characteristics, ease of application, residence time, and low active penetration in the skin. Particularly, the available treatments may have low efficacy, unsatisfactory hemostatic performance, prolonged duration, and adverse effects. In this sense, there is significant growth in research focusing on improving the treatment of wounds. Thus, soft nanoparticles-based hydrogels emerge as promising alternatives to accelerate the healing process due to their improved rheological characteristics, increased occlusion and bioadhesiveness, greater skin permeation, controlled drug release, and a more pleasant sensory aspect in comparison to conventional forms. Soft nanoparticles are based on organic material from a natural or synthetic source and include liposomes, micelles, nanoemulsions, and polymeric nanoparticles. This scoping review describes and discusses the main advantages of soft nanoparticle-based hydrogels in the wound healing process. Herein, a state-of-the-art is presented by addressing general aspects of the healing process, current status and limitations of non-encapsulated drug-based hydrogels, and hydrogels formed by different polymers containing soft nanostructures for wound healing. Collectively, the presence of soft nanoparticles improved the performance of natural and synthetic bioactive compounds in hydrogels employed for wound healing, demonstrating the scientific advances obtained so far.

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How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature

Cited by 21 publications

References 185 publications

Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events

Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events

A Comprehensive Review of the Application of Nanoparticles in Diabetic Wound Healing: Therapeutic Potential and Future Perspectives

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

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