Sustenance of Inclusion Complexes of Ionic Liquid with Cyclic Oligosaccharide Molecules in Liquid and Solid Phases by Diverse Approaches

Abstract

The water soluble inclusion complexes of pyridinium based hydrophobic ionic liquid (IL) were prepared and characterised successfully. The inclusion complexes of sparingly soluble IL prepared with α‐ and β‐cyclodextrin in the mixed solvent medium and in solid state were studied by different physicochemical methodologies. Comparison of the chemical shift of the pure CDs, guest and complexes formed in 1‐H NMR spectra, appearance of the cross peaks in 2D‐ROESY spectra and shift in the band positions in FT‐IR spectra confirmed the formation of inclusion complexes. Surface tension and conductance studies in the mixed solvent system indicated the 1:1 stoichiometric ratio of inclusion complex. Job's plot obtained from UV‐Vis study and the spectra obtained from mass spectrometric study supported the formation as well as the stoichiometry of inclusion complexes. The high binding constant values and calculated values of thermodynamic parameters such as Gibb's free energy, enthalpy and entropy supported the high stability and feasibility of formation of the inclusion complex.

Synthesis and Characterization of Host Guest Inclusion Complexation of Cyclic Oligosaccharide with Industrially Potent Dye in Different Phases by Physicochemical Contrivance

“…All measurements were performed at 298.15 K using a 400 MHz spectrometer. Whenever a guest molecules gets encapsulated inside the hollow cavity of CD molecule, there happens some specific changes in the chemical shift values of the protons in the IC . From the structure of β‐CD molecule, it has been observed that H3 and H5 protons are placed inside the hollow cavity whereas other protons such as H1, H2 and H4 are present at the exterior of the cyclodextrin molecule (Scheme .)…”

Probing Subsistence of Host Guest Inclusion Complexes of Oligosaccharides with Allopurinol for Regulatory Release with the Manifestation of Solvation Consequences

“…In ICs no additional signal is obtained which deny the chance of chemical reaction. Thus, the study provides major information about the formation of the ICs in the solid state [32]. Fig.…”

Exploring inclusion complex of an anti-cancer drug (6-MP) with β-cyclodextrin and its binding with CT-DNA for innovative applications in anti-bacterial activity and photostability optimized by computational study

“…During the formation of IC, the hydrophobic component of the drug (6-MP) molecule enters the hydrophobic hollow of the b-CD molecule, and no covalent link is formed or broken in the IC system. 67,68 Water molecules block the cavity of the b-CD molecule, which is an unfavourable situation. The water molecules are easily replenished when the hydrophobic region of the guest molecule enters the hollow chamber of the b-CD.…”